Korean J Ophthalmol.  1992 Dec;6(2):76-82. 10.3341/kjo.1992.6.2.76.

Reduction of postoperative adhesions in strabismus surgery

• Oh SO
• Lee J

• KMID: 2270694
• DOI: http://doi.org/10.3341/kjo.1992.6.2.76

Abstract

An animal experiment was done to evaluate the efficacy of tissue coating with sodium hyaluronic acid and subconjunctival injection of triamcinolone acetate in reducing the severity of postoperative adhesions following strabismus surgery. Experimental animals underwent a mild traumatic surgical procedure in one superior rectus muscle and a severe traumatic surgical procedure in the other superior rectus muscle. Each group was divided into control group, sodium hyaluronate coating group and triamcinolone acetonide injection group. Grading the severity of adhesions through surgical exploration of operative sites and histological comparison after 4 weeks revealed a significant reduction of postoperative adhesions in sodium hyaluronate group compared with control group under conditions of severe surgical trauma. But triamcinolone groups have no significant differences compared with control groups by statistical analysis. Tissue protection afforded by sodium hyaluronate may lead to an effective method which minimizes the surgical trauma to the tissues and reduces the postsurgical adhesions following strabismus surgery.

Keyword

sodium hyaluronate; postoperative adhesion; strabismus surgery; tissue protection

MeSH Terms

Animals
Eye Diseases/etiology/*prevention & control
Hyaluronic Acid/administration & dosage/*therapeutic use
Injections
Oculomotor Muscles/pathology
Postoperative Complications/prevention & control
Rabbits
Strabismus/*surgery
Tissue Adhesions/prevention & control
Triamcinolone Acetonide/administration & dosage/therapeutic use
Wound Healing
Hyaluronic Acid
Triamcinolone Acetonide