J Korean Ophthalmol Soc.  1998 Sep;39(9):1915-1920.

The Effect of Mitomycin-C Eyedrop on Prevention of Internal Ostium Obstruction after Endonasal Dacryocystorhinostomy

• Lee TS
• Rhee K

Abstract

The authors evaluated the effect of topical mitomycin-C on the prevention of dacryocystorhinostomy internal ostium obstruction as antifibroblastic adjuvant. Topical 0.02% mitomycin-C(MMC) eyedrop was applied postoperatively to conjunctival sac of 75 patients who underwent endoscopic dacryocystorhinostomy-MMC group. MMC was instilled twice a day from postoperative 1 day for 7 days and from postoperative 4th week for 7 days. Properly matched another 75 patients without postoperative adjuvant MMC were compared with MMC goup regarding endoscopic findings, patency rates and other eyedrop complications. The internal ostium were patent in 85% in MMC group, and 77% in MMC and control group, respectively. Endoscopic examination of internal ostium showed mean final diameter of 3.4mm in MMC group and 2.5mm in control. There were no significant complications in MMC group except delayed epithelialization of nasal mucosa which had no relationship with surgical outcome.

Keyword

Topical mitomycin-C; Endoscopic dacryocystorhinostomy; Patency rates; Internal sotium; delayed epithelialization

MeSH Terms

Dacryocystorhinostomy*
Humans
Mitomycin*
Nasal Mucosa
Mitomycin