J Korean Ophthalmol Soc.  2002 Apr;43(4):728-732.

The Effect of Mitomycin C in Endonasal Dacryocystorhinostomy

• Kim YT
• Chung WS

Abstract

PURPOSE: To evaluate the effect of intraoperative 0.2 mg/ml mitomycin C application on the success of endonasal dacryocystorhinostomy.
METHODS
One hundred patients (121 eyes) were randomly divided into two groups. Group A (50 patients, 59 eyes) was treated with 0.2 mg/ml mitomycin C application during endonasal dacryocystorhinostomy and group B (50 patients, 62 eyes) was operated without application of mitomycin C. In group A, mitomycin C soaked cotton swabs were applied to the osteotomy site for five minutes. The surgical success was defined as either symptom free from epiphora or good passage of syringing.
RESULTS
After the follow-up period of 6~24 months (mean 10.2 months), average diameter of mucosal osteum measured 1.17+/-0.52 mm in group A and 1.00+/-0.61 mm in group B. Granuloma around mucosal osteum was noted in 20 eyes of group A and in 31 eyes of group B. Primary success rate was 93.2% in group A and 82.3% in group B. There was no significant difference in mucosal osteum size or success rate between the two groups.
CONCLUSIONS
Adjunctive use of intraoperative mitomycin C may be useful to maintain larger osteotomy size and provide better success rate of endonasal dacryocystorhinostomy.

Keyword

Endonasal dacryocystorhinostomy; Mitomycin C; Mucosal osteum

MeSH Terms

Dacryocystorhinostomy*
Follow-Up Studies
Granuloma
Humans
Lacrimal Apparatus Diseases
Mitomycin*
Osteotomy
Mitomycin