J Korean Continence Soc.  2009 Jun;13(1):7-22.

Review of the Anticholinergics for the Treatment of Overactive Bladder: 2009 Update

• Oh SJ

Abstract

Overactive bladder is a chronic condition defined by bothersome urgency with or without urgency incontinence, usually associated with daytime frequency and nocturia. The treatment of this condition is to control bothersome urinary symptoms and is therefore to improve quality of life. The Korean Continence Society published the overactive bladder guideline in 2007, which suggested the mainstay of management is behavioral therapy and antimuscarinic pharmacotherapy. With growing awareness toward overactive bladder and quality of life, clinical information regarding antimuscarinic agents should be updated. There are several agents with good level of evidence and good grade of recommendation. Newer antimuscarinic agents are available or will be available in near future. The pharmacological properties, efficacy and tolerability of oxybutynin, trospium, propiverine, tolterodine, darifenacin, solifenacin, fesoterodine and imidafenacin are reviewed and discussed here. The results of major clinical studies are summarized.

Keyword

Overactive bladder; Muscarinic antagonists

MeSH Terms

Cholinergic Antagonists*
Drug Therapy
Muscarinic Antagonists
Nocturia
Quality of Life
Urinary Bladder, Overactive*
Solifenacin Succinate
Tolterodine Tartrate
Cholinergic Antagonists
Muscarinic Antagonists