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The effect of atropine in preventing catheter-related pain and discomfort in patients undergoing transurethral resection due to bladder tumor; prospective randomized, controlled study

Şahiner Y, Yağan , Ekici AA, Ekici M, Demir E

Background: Catheter-related bladder discomfort (CRBD) has been observed in many patients undergoing a urethral catheterization. CRBD may be so severe that the patients require additional analgesics. Muscarinic receptors are involved...
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Efficacy and safety of dose escalation in male patients with overactive bladder showing poor efficacy after low-dose antimuscarinic treatment: A retrospective multicenter study

Shim M, Kim JK, Bang WJ, Lee YS, Cho ST, Cho JS, Joo KJ, Hyun JS, Kim BH, Lee JB, Seo YJ, Oh CY

Purpose: To analyze the efficacy and safety of standard-dose antimuscarinic treatment on male patients with overactive bladder (OAB) symptoms showing poor efficacy after low-dose antimuscarinics. Materials and Methods: We retrospectively reviewed...
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Long-Term Efficacy of Mirabegron Add-On Therapy to Antimuscarinic Agents in Patients With Spinal Cord Injury

Han SH, Cho IK, Jung JH, Jang SH, Lee BS

OBJECTIVE: To evaluate the long-term efficacy of mirabegron add-on therapy in patients with spinal cord injury (SCI) based on an urodynamic study. METHODS: This retrospective study involved a chart audit of...
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Influence of solifenacin on the improvement of storage symptoms in the early period after photoselective vaporization of the prostate

Kim SJ, Bae WJ, Kim SW

PURPOSE: We studied the effect of solifenacin on reducing storage symptoms after photoselective vaporization of the prostate (PVP). MATERIALS AND METHODS: This study included patients with persistent storage symptoms of urgency...
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Influence of the Short-term Intake of High Doses of Solifenacin and Trospium on Cognitive Function and Health-Related Quality of Life in Older Women With Urinary Incontinence

Kosilov K, Kuzina I, Loparev S, Gainullina Y, Kosilova L, Prokofyeva A

PURPOSE: The aim of this study was to investigate the safety and the effects of elevated doses of solifenacin and trospium on cognitive function and health-related quality of life (HRQoL)...
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Positioning of Long-Acting Muscarinic Antagonists in the Management of Asthma

Aalbers R, Park HS

Despite a range of efficacious therapies for asthma, including inhaled corticosteroids (ICS) and long-acting β₂-agonists (LABA), a significant proportion of patients have poor asthma control and retain a risk of...
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Long-term adherence to antimuscarinic drugs when treating overactive bladder in the older: Subjective reason and objective factors

Kosilov KV, Loparev SA, Kuzina IG, Geltser BI, Shakirova , Zhuravskaya NS, Lobodenko

PURPOSE: Comparison of subjective reasons for the refusal of antimuscarinic treatment and the state of objective economic, social, psychological and health status markers in the elderly with overactive bladder. MATERIALS AND...
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Social, Economic, and Medical Factors Associated With Solifenacin Therapy Compliance Among Workers Who Suffer From Lower Urinary Tract Symptoms

Kosilov KV, Alexandrovich LS, Gennadyevna KI, Viktorovna SO, Sergeevna , Ivanovich

PURPOSE: The prevalence of hyperactive-type lower urinary tract symptoms is 45.2%, with shares of overactive bladder (OAB) and urge incontinence (UI) symptoms of 10.7% and 8.2%, respectively. We investigated the...
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Persistence and compliance with medication management in the treatment of overactive bladder

Kim TH, Lee KS

Overactive bladder (OAB) is a common and chronic condition that impacts patients' daily activities and quality of life. Pharmaco-therapy for OAB is a mainstay of treatment. Antimuscarinics and beta3-adrenoceptor agonists...
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Factors affecting medication discontinuation in patients with overactive bladder symptoms

Shim EJ, Yoo EH, Kim YM, Kim D

OBJECTIVE: To find out the factors affecting medication discontinuation in patients with overactive bladder (OAB) symptoms. METHODS: The clinical data of 125 patients with OAB symptoms who had taken antimuscarinics and...
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Clinical Factors Associated With Dose Escalation of Solifenacin for the Treatment of Overactive Bladder in Real Life Practice

Chun JY, Song M, Han JY, Na S, Hong B, Choo MS

  • KMID: 2232917
  • Int Neurourol J.
  • 2014 Mar;18(1):23-30.
PURPOSE: To determine the baseline clinical characteristics associated with dose escalation of solifenacin in patients with overactive bladder (OAB). METHODS: We analyzed the data of patients with OAB (micturition frequency >...
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Maintenance of the Therapeutic Effect of Two High-Dosage Antimuscarinics in the Management of Overactive Bladder in Elderly Women

Kosilov K, Loparev S, Ivanovskaya M, Kosilova L

  • KMID: 2233008
  • Int Neurourol J.
  • 2013 Dec;17(4):191-196.
PURPOSE: To improve the long-term efficiency of the pharmacologic management of overactive bladder (OAB) in elderly women. METHODS: The study comprised 229 women (mean age, 66.3 years; range, 65-77 years) with...
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Characterization of Bladder Selectivity of Antimuscarinic Agents on the Basis of In Vivo Drug-Receptor Binding

Yamada S, Kuraoka S, Osano A, Ito Y

  • KMID: 2232961
  • Int Neurourol J.
  • 2012 Sep;16(3):107-115.
The in vivo muscarinic receptor binding of antimuscarinic agents (oxybutynin, solifenacin, tolterodine, and imidafenacin) used to treat urinary dysfunction in patients with overactive bladder is reviewed. Transdermal administration of oxybutynin...
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Bladder Wall Thickness is Associated with Responsiveness of Storage Symptoms to Alpha-Blockers in Men with Lower Urinary Tract Symptoms

Park JS, Lee HW, Lee SW, Moon HS, Park HY, Kim YT

PURPOSE: Bladder wall thickness (BWT) is reported to be related to detrusor overactivity and bladder outlet obstruction. We investigated the relationship between BWT and the responsiveness of storage symptoms to...
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Issues on Safety of Long-Acting Muscarinic Antagonist

Lee YD, Cho Y, Han MS

  • KMID: 2319504
  • Tuberc Respir Dis.
  • 2011 May;70(5):384-389.
The prevention of and the controlling of symptoms, reductions in the frequency of exacerbations, and disease severity are central to the pharmacologic therapy of chronic obstructive pulmonary disease (COPD). COPD...
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Review of the Anticholinergics for the Treatment of Overactive Bladder: 2009 Update

Oh SJ

  • KMID: 2331537
  • J Korean Continence Soc.
  • 2009 Jun;13(1):7-22.
Overactive bladder is a chronic condition defined by bothersome urgency with or without urgency incontinence, usually associated with daytime frequency and nocturia. The treatment of this condition is to control...
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Effects of Intravesical Instillation of Antimuscarinics on Bladder Overactivity Induced by Intravesical Instillation of Adenosine Triphosphate in Rats

Lee SB, Lee JW, Kim YT

  • KMID: 2311867
  • Korean J Urol.
  • 2009 Apr;50(4):396-400.
PURPOSE: Adenosine triphosphate (ATP) from the urothelium acts as a sensory neurotransmitter and is augmented in many diseases, such as overactive bladder. We investigated the effects of intravesical instillation of...
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Local Effects of Antimuscarinics on Muscarinic Receptors in Bladder Sensory Nerves

Park MS, Cho SW, Han KH, Lee SC, Kim WJ, Kim YT

  • KMID: 2330522
  • J Korean Continence Soc.
  • 2006 Jun;10(1):17-22.
PURPOSE: To investigate the role of muscarinic receptors in bladder sensory mechanism. MATERIALS AND METHODS: Normal adult volunteers collected voided urine after taking five days of trospium(20 mg bid), tolterodine LA(4...
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Efficacy and Tolerability of Tolterodine Compared to Oxybutynin in Children with a Neurogenic Bladder

Kim KM, Lee SW

  • KMID: 2294073
  • Korean J Urol.
  • 2005 Jun;46(6):598-603.
PURPOSE: The aim of this study was to investigate the efficacy and adverse effects of oral tolterodine compared to oxybutynin in children with a neurogenic bladder. MATERIALS AND METHODS: 16 patients,...
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