J Rheum Dis.
2016 Jun;23(3):148-153. 10.4078/jrd.2016.23.3.148.
Pro-inflammatory Cytokines Modulating Osteoclast Differentiation and Function
- Affiliations
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- 1Department of Pharmacology, Chonnam National University Medical School, Gwangju, Korea. nacksung@jnu.ac.kr
- 2Department of Biomedical Sciences, Chonnam National University Medical School, Gwangju, Korea.
- KMID: 2326729
- DOI: http://doi.org/10.4078/jrd.2016.23.3.148
Abstract
- In general, bone homeostasis is maintained through the balance between bone formation and resorption. Disruption in this balance results in bone-related diseases such as osteopetrosis, osteoporosis, and rheumatoid arthritis. Often, enhanced osteoclastogenesis is followed by accelerated bone resorption that is induced by pro-inflammatory cytokines in osteoporosis or rheumatoid arthritis, and leads to bone destruction. In this review study, factors involved in osteoclast differentiation and function are discussed, and how the prevention of such factors is effective in ameliorating bone loss in osteoporosis or rheumatoid arthritis.
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