J Korean Surg Soc.  2002 May;62(5):396-402.

Correlation between Expression of Insulin-like Growth Factor-I Receptor and Clinicopathologic Prognostic Factors in Invasive Ductal Carcinoma of the Breast

• Oh SY
• Kang MJ
• Moon WS
• Choi HY

Abstract

PURPOSE: The insulin-like growth factor-I receptor (IGF-IR) is a member of the transmembrane tyrosine kinase family that regulates various biological processes. These processes include maintaining optimal cell growth, establishing and maintaining the transformed phenotype, tumorigenesis for several types of cells, and antiapoptosis. This study investigated the immunohistochemical expression of IGF-IR in relation with the expression of the estrogen receptor (ER), the progesteron receptor (PR), proliferative activity (Ki-67) as well as with the other conventional clinicopathlogical parameters in breast cancer.
METHODS
This study was performed on paraffin sections from 64 invasive ductal breast carcinoma specimens by immunohistochemistry using rabbit polyclonal antibodies to the IGF-I receptor.
RESULTS
IGF-IR expression was detected in 56 (87.5%) cases. The immunohistochemical stains for the IGF-IR were scored according to a semi quantitative scoring system. IGF-IR staining was positively correlated with the ER status, but not significantly with the PR, lymph node status, tumor size, histological grade, and proliferative activity. The Ki-67 labeling index showed a significant correlation with the tumor grade and ER status.
CONCLUSION
The IGF-IR may play a role in estrogen-mediated growth and the pathogenesis of breast cancer.

Keyword

Breast cancer; IGF-I receptor; Estrogen receptor; Progesteron receptor; Ki-67

MeSH Terms

Antibodies
Biological Processes
Breast Neoplasms
Breast*
Carcinogenesis
Carcinoma, Ductal*
Coloring Agents
Estrogens
Humans
Immunohistochemistry
Lymph Nodes
Paraffin
Phenotype
Protein-Tyrosine Kinases
Receptor, IGF Type 1
Antibodies
Coloring Agents
Estrogens
Paraffin
Protein-Tyrosine Kinases
Receptor, IGF Type 1