J Korean Soc Traumatol.  2007 Jun;20(1):1-5.

Treatment of Partial Thickness Skin Defect with Cultured Allogenic Keratinocytes (Kaloderm.)

• Seo SW
• Chang CH
• Cho MS
• Hong YG
• Jeon SW

Abstract

PURPOSE: Grafting with autograft skin remains the most effective method for treating skin defects. When insufficient donor sites are present or patients are afraid of the operation, a skin graft is impossible. Cultured allogenic keratinocytes speed wound healing by providing cover and by producing growth factors and extracellular matrix protein. We report an application of cultured allogenic keratinocytes (Kaloderm., Tegoscience, Seoul, Korea) in the treatment of an acute partial thickness skin defect.
METHODS
From March 2005 to January 2006, 20 patients with a partial thickness skin defect were treated with cultured allogenic keratinocytes. The wound was covered with a sheet of cultured allogenic keratinocytes and ointment with Bactigras. gauze. The wound was inspected every two or three days. We regarded completion of epithelialization as wound healing.
RESULTS
The mean period between time of injury and time of Kaloderm. application was 7.5 days. The time taken from application of Kaloderm. to complete closure of the wounds was 7.2 days.
CONCLUSION
In view of the favorable outcome, cultured allogenic keratinocytes are safe and effective biologic dressing materials for use in the treatment of open wounds.

Keyword

Cultured allogenic keratinocyte; Partial thickness wound

MeSH Terms

Autografts
Biological Dressings
Extracellular Matrix
Humans
Intercellular Signaling Peptides and Proteins
Keratinocytes*
Seoul
Skin*
Tissue Donors
Transplants
Wound Healing
Wounds and Injuries
Intercellular Signaling Peptides and Proteins