J Korean Acad Rehabil Med.  1999 Oct;23(5):961-967.

Relationship between Nocturnal Polyuria and Antidiuretic Hormone in Chronic Spinal Cord Injury

• Yu JY
• Shin KH
• Kim JT
• Bae JH
• Park YO
• Cho YJ

Abstract

OBJECTIVE
To delineate the role of antidiuretic hormone (ADH) in relation to nocturnal polyuria, and to identify the factors influencing on the diurnal antidiuretic hormone level. METHOD: The ADH was measured by radioimmuoassay at daytime (2:00 PM) and at nighttime (2:00 AM) with nocturnal polyuria group (11) and without nocturnal polyuria group (8). Urine volume, serum osmolarity, urine osmolarity, and blood pressure were also measured at the same time.
RESULTS
1) The ADH at 2:00 AM did not increase in nocturnal polyuria group, although it increased in no-symptom group. 2) There was a statistically significant correlation between wheelchair ambulation time and daytime ADH level. 3) The difference of ADH level between daytime and nighttime showed decrease in orthostatic hypotension group.
CONCLUSION
There was relationship between nocturnal polyuria and diurnal variation of ADH level. The ADH concentration seems to be influenced by the postural factors and sympathetic factors.

Keyword

Antidiuretic hormone; Nocturnal polyuria; Serum osmolarity; Urine osmolarity; Orthostatic hypotension

MeSH Terms

Blood Pressure
Hypotension, Orthostatic
Osmolar Concentration
Polyuria*
Spinal Cord Injuries*
Spinal Cord*
Walking
Wheelchairs