J Korean Acad Rehabil Med.  1998 Dec;22(6):1232-1238.

Diurnal Variation of Plasma Anti-Diuretic Hormone and Relationship to Nocturnal Polyuria after Spinal Cord Injured Patients

• Sung IY
• Song SH

Abstract

OBJECTS: To investigate the effect of anti-diuretic hormone (ADH) on nocturnal polyuria in spinal cord injured patients.
METHODS
Eleven quadriplegics, seven paraplegics, and nine normal person participated in this study. Quadriplegics and paraplegics ranged from A to C grades according to the ASIA classification. All participants were independent in activities of daily living on wheelchair level. Their intake and output were measured at every 6 hours for 24 hours. The level of ADH was measured by the radioimmunoassay method.
RESULTS
1) Urine output from midnight to 6:00 A.M. was increased in quadriplegics, but not in paraplegics. 2) ADH at 6:00 A.M. and midnight was decreased in quadriplegics than in controls. No significant change of ADH level was noted in paraplegics. 3) Serum osmolality was higher in quadriplegics than in controls at 6:00 A.M. and midnight.
CONCLUSION
This study indicates that the nocturnal polynuria in spinal cord injured patient is partly due to a decreased ADH.

Keyword

Spinal cord injury; Nocturnal polyuria; Anti-diuretic hormone(ADH)

MeSH Terms

Activities of Daily Living
Asia
Classification
Humans
Osmolar Concentration
Plasma*
Polyuria*
Radioimmunoassay
Spinal Cord Injuries
Spinal Cord*
Wheelchairs