J Korean Soc Osteoporos.  2010 Aug;8(2):152-159.

Relationship Between Bone Mineral Density and Risk Factors of Atherosclerosis and Cardiovascular Disease in Korean Postmenopausal Women

• Kong EH
• Lee JY
• Choi WH
• Oh YL
• Kim HY

Abstract

OBJECTIVES
We investigated the associations between bone mineral density (BMD) and the risk factors for atherosclerosis and cardiovascular disease (CVD) in Korean postmenopausal women who were enrolled in a health promotion center of a university hospital from January, 2007 to December, 2009.
METHODS
The risk factors of atherosclerosis and CVD were a current smoker, no regular exercise, obesity, abdominal obesity, hypercholesterolemia, low levels of high density lipoprotein cholesterol, high levels of low density lipoprotein cholesterol, hypertriglyceridemia, hypertension, and diabetes mellitus. Metabolic syndrome was used as an endpoint of the risk factors for atherosclerosis and CVD. The BMD measures of the subjects were assessed using dual-energy X-ray absorptiometry. Data on their lifestyle, their current medical diseases and their medications was collected during a personal interview with using a questionnaire at the initial examination. Height, body weight, waist circumference, blood pressure, fasting blood glucose and the serum lipid profiles were measured.
RESULTS
In the adjusted analysis with including age and the body mass index, blood pressure and the triglyceride level had a close correlation with BMD (P<0.05). After adjustment for age, waist circumference, systolic- and diastolic blood pressure, BMD revealed significant correlation with the presence of metabolic syndrome (P=0.037).
CONCLUSION
BMD measures in Korean postmenopausal women with no prior history of cardiovascular disease were inversely related to metabolic syndrome, independent of age, waist circumference, systolic and diastolic blood pressure, total cholesterol and triglyceride as risk factors for atherosclerosis and CVD.

Keyword

Risk factors of cardiovascular disease; Bone mineral density; Postmenopausal women

MeSH Terms

Absorptiometry, Photon
Atherosclerosis
Blood Glucose
Blood Pressure
Body Height
Body Mass Index
Bone Density
Cardiovascular Diseases
Cholesterol
Cholesterol, HDL
Cholesterol, LDL
Diabetes Mellitus
Fasting
Female
Health Promotion
Humans
Hypercholesterolemia
Hypertension
Hypertriglyceridemia
Life Style
Lipoproteins
Obesity
Obesity, Abdominal
Surveys and Questionnaires
Risk Factors
Waist Circumference
Blood Glucose
Cholesterol
Cholesterol, HDL
Cholesterol, LDL
Lipoproteins