Yeungnam Univ J Med.  2011 Jun;28(1):1-12.

Combined Hepatocellular-Cholangiocarcinoma: Recent Progress in Pathology and Classification

• Choi JH

Abstract

Primary liver carcinomas have been classified into hepatocellular carcinoma, cholangiocarcinoma, and combined hepatocellular-cholangiocarcinoma (CHC). CHC is a tumor containing unequivocal, intimately mixed elements of both hepatocellular carcinoma and cholangiocarcinoma. It forms a small but significant proportion of primary liver carcinomas. The origin and pathogenesis of CHC have not been well established. According to the 2010 WHO classification, CHCs are categorized into 2 groups: the classical type and a subtype with stem cell features. This review describes recent progress in pathology and classification of CHC.

Keyword

Liver; Combined hepatocellular-cholangiocarcinoma; Immunohistochemistry; Stem cell; Classification

MeSH Terms

Carcinoma, Hepatocellular
Cholangiocarcinoma
Immunohistochemistry
Liver
Stem Cells