Korean J Hepatol.  2004 Jun;10(2):142-147.

A Case of Combined Hepatocellular-Cholangiocarcinoma with Sarcomatous Transformation and Second Primary Colon Cancer

• Kim JH
• Lee YG
• Lee J
• Jung CK
• Kim HT
• Kang H
• Kho KH
• Hong SP
• Hwang SG
• Park PW
• Rim GS

Abstract

Combined hepatocellular-cholangiocarcinoma is a rare form of primary liver cancer, featuring both hepatocellular and biliary epithelial differentiations. An intrahepatic tumor may be considered as a metastatic lesion. It has been suggested in the literature that the likelihood of metastasis in the cirrhotic liver is lower than that in the non-cirrhotic liver. A rare case of combined hepatocellular-cholangiocarcinoma and second primary colon adenocarcinoma in a 67-year-old male patient with liver cirrhosis is presented. Histologically, the intrahepatic mass was composed of a spindle cell sarcomatous component; a hepatocellular carcinoma component; and a cholangiocarcinoma component. There were focal transitional regions among the different components. Immunohistochemically, the cholangiocarcinoma component of the intrahepatic mass showed positive reactions for CK-7 but negative reactions for CK-20. The adenocarcinoma of the colon showed positive reactions for CK-20 but negative reactions for CK-7.

Keyword

Neoplasm/Liver/Combined hepatocellular-cholangiocarcinoma; Colon neoplasms; Second primary cancer

MeSH Terms

Adenocarcinoma/*pathology
Aged
Bile Duct Neoplasms/*pathology
*Bile Ducts, Intrahepatic
Carcinoma, Hepatocellular/*pathology
Cholangiocarcinoma/*pathology
Colonic Neoplasms/*pathology
English Abstract
Humans
Liver Neoplasms/*pathology
Male
Neoplasms, Second Primary/*pathology