Psychiatry Investig.  2011 Sep;8(3):262-268.

Genetic Polymorphisms in the HTR2C and Peroxisome Proliferator-Activated Receptors Are Not Associated with Metabolic Syndrome in Patients with Schizophrenia Taking Clozapine

• Kang SH
• Lee JI
• Chang AK
• Joo YH
• Kim CY
• Kim SY

Abstract

OBJECTIVE
Genetic variation in the serotonin-2C receptor encoded by the HTR2C gene is one of the genetic determinants of antipsychotic-induced weight gain. Peroxisome proliferator-activated receptors are nuclear receptors regulating the expression of genes involved in lipid and glucose metabolism. In this cross-sectional study, we investigated whether HTR2C-759C/T, HTR2C-697G/C, PPARalpha V227A, and PPARgamma 161C/T genotypes were associated with metabolic syndrome (MetS) in patients with schizophrenia taking clozapine.
METHODS
One hundred forty-six Korean patients using clozapine for more than one year were genotyped for the HTR2C-759C/T, HTR2C-697G/C, PPARalpha V227A, and PPARgamma 161C/T polymorphisms, and their weight, waist circumference, blood pressure, triglycerides, high-density lipoprotein-cholesterol, total cholesterol, and glucose were measured. We used the criteria for MetS proposed by the National Cholesterol Education Program-adapted Adult Treatment Panel III.
RESULTS
The prevalence of MetS was 47.3% and was similar among men (49%) and women (42.9%). We found no significant differences between patients with and without MetS in terms of genotypes or allele frequencies. Logistic regression analyses also revealed no association between MetS and each genotype.
CONCLUSION
We did not find significant associations between four polymorphisms (HTR2C-759C/T, HTR2C-697G/C, PPARalpha V227A, and PPARgamma 161C/T) and MetS in patients with schizophrenia taking clozapine.

Keyword

Metabolic syndrome; Clozapine; HTR2C; PPAR; Polymorphism; Schizophrenia

MeSH Terms

Adult
Blood Pressure
Cholesterol
Clozapine
Cross-Sectional Studies
Female
Gene Frequency
Genetic Variation
Genotype
Glucose
Humans
Logistic Models
Male
Peroxisome Proliferator-Activated Receptors
Peroxisomes
Polymorphism, Genetic
PPAR alpha
PPAR gamma
Prevalence
Receptors, Cytoplasmic and Nuclear
Schizophrenia
Triglycerides
Waist Circumference
Weight Gain
Cholesterol
Clozapine
Glucose
PPAR alpha
PPAR gamma
Peroxisome Proliferator-Activated Receptors
Receptors, Cytoplasmic and Nuclear
Triglycerides