- Refocusing Peroxisome Proliferator Activated Receptor-alpha: A New Insight for Therapeutic Roles in Diabetes
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Seok H, Cha BS
- KMID: 1965978
- Diabetes Metab J.
- 2013 Oct;37(5):326-332.
- doi: 10.4093/dmj.2013.37.5.326
Although glucose-lowering treatment shows some risk lowering effects in cardiovascular diseases, risks of macrovascular and microvascular complications have still remained, and development of new therapeutic strategies is needed. Recent data... -
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- Downregulation of Peroxisome Proliferator-Activated Receptor (PPAR)alpha, PPARgamma, and Phosphoglycerate Mutase 2 in Prostate Cancer
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Cho HJ, Kim DY, Kim JW, Yoo TK, Yang EK
- KMID: 2294244
- Korean J Urol.
- 2006 Jun;47(6):661-666.
- doi: 10.4111/kju.2006.47.6.661
PURPOSE: To evaluate whether factors related to lipid and glucose metabolism have a potential role in the progression of prostate cancer, we measured the mRNA levels of the peroxisome proliferator-activated... -
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- Role of Peroxisome Proliferator-Activated Receptor alpha in Diabetic Nephropathy
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Chung S, Park CW
- KMID: 2281638
- Diabetes Metab J.
- 2011 Aug;35(4):327-336.
- doi: 10.4093/dmj.2011.35.4.327
With a developing worldwide epidemic of diabetes mellitus, the renal complications associated with diabetes have become a serious health concern. Primary therapy for treating diabetic nephropathy is a multifactorial process.... -
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- Identification and characterization of peroxisome proliferator response element in the mouse GLUT2 promoter
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Im SS, Kim JW, Kim TH, Song XL, Kim SY, Kim HI, Ahn YH
- KMID: 755748
- Exp Mol Med.
- 2005 Apr;37(2):101-110.
In the present study, we show that the expression of type 2 glucose transporter isoform (GLUT2) could be regulated by PPAR-gamma in the liver. Rosiglitazone, PPAR-gamma agonist, activated the GLUT2... -
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- Activation of PPARgamma induces profound multilocularization of adipocytes in adult mouse white adipose tissues
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Koh YJ, Park BH, Park JH, Han J, Lee IK, Park JW, Koh GY
- KMID: 1099865
- Exp Mol Med.
- 2009 Dec;41(12):880-895.
- doi: 10.3858/emm.2009.41.12.094
We sought to determine the effects of activation of peroxisome proliferator-activated receptor-gamma (PPAR-gamma) on multilocularization of adipocytes in adult white adipose tissue (WAT). Male C57BL/6 normal, db/db, and ob/ob mice... -
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- Expression of peroxisome proliferator-activated receptor (PPAR)-alpha and PPAR-gamma in the lung tissue of obese mice and the effect of rosiglitazone on proinflammatory cytokine expressions in the lung tissue
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Ryu SL, Shim JW, Kim DS, Jung HL, Park MS, Park SH, Lee J, Lee WY, Shim JY
- KMID: 1427931
- Korean J Pediatr.
- 2013 Apr;56(4):151-158.
- doi: 10.3345/kjp.2013.56.4.151
PURPOSE: We investigated the mRNA levels of peroxisome proliferator-activated receptor (PPAR)-alpha, PPAR-gamma, adipokines, and cytokines in the lung tissue of lean and obese mice with and without ovalbumin (OVA) challenge,... -
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- The Effects of Dietary Interventions on mRNA Expression of Peroxisome Proliferator Activated Receptor Isoforms (PPAR Isoforms)in Rat Skeletal Muscle
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Lee J, Kim J, Moon H, Shin Y, Lee J
- KMID: 2259921
- Korean J Nutr.
- 2007 Apr;40(3):221-228.
We determined the effects of dietary manipulations on messenger RNA of peroxisome proliferators activated receptor isoforms (i.e., PPAR alpha, beta/delta, gamma)in red vastus lateralis muscle of rats. Total 16 male Sprague-Dawley... -
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- Exercise and Fenofibrate Reduces Body Adiposity Synergistically in OLETF Rats
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An YJ, Lee HJ, Park MK, Lee KI, Koh IY, Jung DS, Kang AY, Kim DK
- KMID: 2063414
- J Korean Diabetes Assoc.
- 2004 Apr;28(2):131-138.
BACKGROUND: The PPAR alpha activator, Fenofibrate, is a pharmacological ligand, which induces beta-oxidation of long chain fatty acids in the mitochondria of hepatocytes. The beta-oxidation induced by exogenous PPAR alpha... -
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- Fenofibrate, a peroxisome proliferator-activated receptor alpha-agonist, blocks lipopolysaccharide-induced inflammatory pathways in mouse liver
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Won TW
- KMID: 1472524
- Korean J Hepatobiliary Pancreat Surg.
- 2013 Aug;17(3):89-108.
- doi: 10.14701/kjhbps.2013.17.3.89
BACKGROUNDS/AIMS: During the acute phase response, cytokines induce marked alterations in lipid metabolism including an increase in serum triglyceride levels and a decrease in hepatic fatty acid oxidation, in bile... -
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- Fenofibrate decreases radiation sensitivity via peroxisome proliferator-activated receptor alpha-mediated superoxide dismutase induction in HeLa cells
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Liu X, Jang SS, An Z, Song H, Kim WD, Yu JR, Park WY
- KMID: 1494299
- Radiat Oncol J.
- 2012 Jun;30(2):88-95.
- doi: 10.3857/roj.2012.30.2.88
PURPOSE: The fibrates are ligands for peroxisome proliferator-activated receptor (PPAR) alpha and used clinically as hypolipidemic drugs. The fibrates are known to cause peroxisome proliferation, enhance superoxide dismutase (SOD) expression... -
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- Effects of Caloric Restriction on the Expression of PGC-1 and PPARs mRNA in Liver of Otsuka Long-Evans Tokushima Fatty Rats
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Kim SY, Kim JH, Bae HY, Lee BR
- KMID: 2177607
- J Korean Diabetes Assoc.
- 2006 May;30(3):161-169.
- doi: 10.4093/jkda.2006.30.3.161
BACKGROUND: Gluconeogenesis is strongly stimulated during fasting and is aberrantly activated in diabetes mellitus. PPARgamma-coactivator 1 (PGC-1) and Peroxisome proliferator -activated receptors (PPARs) costimulate the expression of key enzymes of... -
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- Fenofibrate Reduces Age-related Hypercholesterolemia in Normal Rats on a Standard Diet
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Han Y, Do MH, Kim MS, Seo E, Park MK, Kim DK, Lee HJ, Seo SY
- KMID: 1457672
- Korean J Physiol Pharmacol.
- 2010 Apr;14(2):77-81.
- doi: 10.4196/kjpp.2010.14.2.77
Plasma cholesterol is increased in normal aging in both rodents and humans. This is associated with reduced elimination of cholesterol and decreased receptor-mediated clearance of plasma low-density lipoprotein (LDL) cholesterol.... -
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- Genetic Polymorphisms in the HTR2C and Peroxisome Proliferator-Activated Receptors Are Not Associated with Metabolic Syndrome in Patients with Schizophrenia Taking Clozapine
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Kang SH, Lee JI, Chang AK, Joo YH, Kim CY, Kim SY
- KMID: 2316094
- Psychiatry Investig.
- 2011 Sep;8(3):262-268.
OBJECTIVE: Genetic variation in the serotonin-2C receptor encoded by the HTR2C gene is one of the genetic determinants of antipsychotic-induced weight gain. Peroxisome proliferator-activated receptors are nuclear receptors regulating the... -
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- Betaine Alleviates Hypertriglycemia and Tau Hyperphosphorylation in db/db Mice
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Jung GY, Won SB, Kim J, Jeon S, Han A, Kwon YH
- KMID: 2317810
- Toxicol Res.
- 2013 Mar;29(1):7-14.
Betaine supplementation has been shown to alleviate altered glucose and lipid metabolism in mice fed a high-fat diet or a high-sucrose diet. We investigated the beneficial effects of betaine in... -
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- Activation of PPARalpha Attenuates IFNgamma and IL-1beta-induced Cell Proliferation in Astrocytes: Involvement of IL-6 Independent Pathway
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Lee JK, Seo EM, Lee SS, Park SH, Sim YB, Jung JS, Kim SM, Suh HW
- KMID: 2285401
- Korean J Physiol Pharmacol.
- 2010 Jun;14(3):185-189.
- doi: 10.4196/kjpp.2010.14.3.185
The present study demonstrates the effect of fibrates, agonists of PPARalpha on cytokines-induced proliferation in primary cultured astrocytes. Alone or combination treatment with cytokines, such as IL-1beta (10 ng/ml), IFNgamma... -
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- Anti-obesity effects of hot water extract from Wasabi (Wasabia japonica Matsum.) leaves in mice fed high-fat diets
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Yamasaki M, Ogawa T, Wang L, Katsube T, Yamasaki Y, Sun X, Shiwaku K
- KMID: 2313679
- Nutr Res Pract.
- 2013 Aug;7(4):267-272.
The anti-obesity effects of a hot water extract from wasabi (Wasabia japonica Matsum.) leaves (WLE), without its specific pungent constituents, such as allyl-isothiocyanate, were investigated in high fat-diet induced mice.... -
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- The Effects of Peroxisome Proliferator Activated Receptor alpha (PPARalpha) Activator on Patients with Facial Erythema
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Kim Y, Jung Y, Youm J, Park J, Bae YI, Park Y, Lee S
- KMID: 2089032
- Korean J Dermatol.
- 2014 Sep;52(9):608-614.
BACKGROUND: Long-term use of topical steroids for inflammatory skin diseases can induce complications, and efforts to find a better treatment are being continued. Peroxisome proliferator activated receptor alpha (PPARalpha) suppresses... -
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- Deficiency or activation of peroxisome proliferator-activated receptor α reduces the tissue concentrations of endogenously synthesized docosahexaenoic acid in C57BL/6J mice
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Hsiao WT, Su HM, Su KP, Chen SH, Wu HP, You YL, Fu RH, Chao PM
- KMID: 2453106
- Nutr Res Pract.
- 2019 Aug;13(4):286-294.
- doi: 10.4162/nrp.2019.13.4.286
BACKGROUND/OBJECTIVES: Docosahexaenoic acid (DHA), an n-3 long chain polyunsaturated fatty acid (LCPUFA), is acquired by dietary intake or the in vivo conversion of α-linolenic acid. Many enzymes participating in LCPUFA... -
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- A Novel Cytosolic Isoform of Mitochondrial Trans-2-Enoyl-CoA Reductase Enhances Peroxisome Proliferator-Activated Receptor alpha Activity
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Kim DG, Yoo JC, Kim E, Lee YS, Yarishkin , Lee DY, Lee KH, Hong SG, Hwang EM, Park JY
- KMID: 2169426
- Endocrinol Metab.
- 2014 Jun;29(2):185-194.
- doi: 10.3803/EnM.2014.29.2.185
BACKGROUND: Mitochondrial trans-2-enoyl-CoA reductase (MECR) is involved in mitochondrial synthesis of fatty acids and is highly expressed in mitochondria. MECR is also known as nuclear receptor binding factor-1, which was... -
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- Triglyceride-Rich Lipoproteins and Novel Targets for Anti-atherosclerotic Therapy
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Reiner Z
- KMID: 2424560
- Korean Circ J.
- 2018 Dec;48(12):1097-1119.
- doi: 10.4070/kcj.2018.0343
Although elevated serum low-density lipoprotein-cholesterol (LDL-C) is without any doubts accepted as an important risk factor for cardiovascular disease (CVD), the role of elevated triglycerides (TGs)-rich lipoproteins as an independent... -
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