Pediatr Gastroenterol Hepatol Nutr.  2012 Mar;15(1):19-22.

Recent Trends of Infliximab Treatment for Crohn's Disease

• Kim MJ
• Choe YH

Abstract

Crohn's disease is a chronic inflammatory disorder of the gastrointestinal tract and characterized by relapsing and remitting episodes, with progression over time to complications of stricture, fistulas, or abscesses. The etiology is unknown, although the common opinion is that the disease arises from a disordered immune response to the gut contents in genetically predisposed individuals. Infliximab is a mouse-human chimeric antibody against tumor necrosis factor alpha, and has proven to be effective in active Crohn's disease for both induction and maintenance therapy. Despite the growing experience with infliximab in Crohn's disease, optimal treatment strategies still need to be determined. The purpose of this review is to summarize the current knowledge on the use of infliximab in Crohn's disease and to discuss the yet-unsolved issues.

Keyword

Crohn's disease; Infliximab

MeSH Terms

Abscess
Antibodies, Monoclonal
Constriction, Pathologic
Crohn Disease
Fistula
Gastrointestinal Tract
Tumor Necrosis Factor-alpha
Infliximab
Antibodies, Monoclonal
Tumor Necrosis Factor-alpha

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