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Interactions Between Atopic Dermatitis and Staphylococcus aureus Infection: Clinical Implications

Kim J, Kim BE, Ahn K, Leung DY

Staphylococcus aureus commonly colonizes the skin of atopic dermatitis (AD) patients and contributes to the development and exacerbation of AD. Multiple factors are associated with colonization of AD skin by...
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Measurement of Tumor Pressure and Strategies of Imaging Tumor Pressure for Radioimmunotherapy

Kim HG, Yu AR, Lee JJ, Lee YJ, Lim SM, Kim JS

Tumor interstitial pressure is a fundamental feature of cancer biology. Elevation in tumor pressure affects the efficacy of cancer treatment and results in the heterogenous intratumoral distribution of drugs and...
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The Incidence and Immunophenotypic and Genetic Features of JL1 Expressing Cells and the Therapeutic Potential of an Anti-JL1 Antibody in De Novo Pediatric Acute Leukemias

Park SH, You E, Park CJ, Jang S, Cho YU, Yoon CH, Koh KN, Im HJ, Seo JJ

BACKGROUND: JL1 is a newly identified CD43 epitope that specifically recognizes leukemic cells. We analyzed the incidence of JL1 expression and compared the clinical, immunophenotypic, and genetic characteristics of de...
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Detection of Streptococcus mutans in human saliva and plaque using selective media, polymerase chain reaction, and monoclonal antibodies

Lee YJ, Kim MA, Kim JG, Kim JH

The objective of this study was to evaluate the distribution of dental caries-associated Streptococcus mutans in human saliva and plaque. The samples for this study were collected from 90 subjects...
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Development and Clinical Evaluation of a Rapid Diagnostic Test for Yellow Fever Non-Structural Protein 1

Kim YH, Kim TY, Park JS, Park JS, Lee J, Moon J, Chong CK, Junior IN, Ferry FR, Ahn HJ, Bhatt L, Nam HW

A rapid diagnostic test (RDT) kit was developed to detect non-structural protein 1 (NS1) of yellow fever virus (YFV) using monoclonal antibody. NS1 protein was purified from the cultured YFV...
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Management of severe hidradenitis suppurativa with biologic therapy and wide excision

Lim SY, Cheong EC, Oon HH

Hidradenitis suppurativa (HS) is a chronic inflammatory follicular occlusive disease that involves the intertriginous areas. Treatment methods include conventional topical and systemic medication, radiotherapy, biologic agents, and surgical excision. Of...
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Progress of Coordination and Utilization of Zirconium-89 for Positron Emission Tomography (PET) Studies

La MT, Tran VH, Kim HK

Radiometals have been commonly used in medical applications, and utilization of such metals continues to be an attractive research area. In particular, a variety of radiometals have been developed and...
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Higher Binding Affinity and In Vitro Potency of Reslizumab for Interleukin-5 Compared With Mepolizumab

Liddament , Husten J, Estephan T, Laine D, Mabon D, Pukac L, Lyons J, Clarke AW, Doyle A

Reslizumab and mepolizumab are recently approved monoclonal antibodies for the treatment of severe (uncontrolled) eosinophilic asthma. Both are effective in neutralizing the function of interleukin-5 (IL-5). This study is the...
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Knowledge and Viewpoints on Biosimilar Monoclonal Antibodies among Asian Physicians: Comparison with European Physicians

Park SK, Moon W, Kim ES, Park SH, Park DI

BACKGROUND/AIMS: Current knowledge and viewpoints regarding biosimilars among physicians in Asia are unknown, even though these were investigated by European Crohn's and Colitis Organization (ECCO) members in 2013 and 2015....
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Cancer Immunotherapy Related Endocrine Adverse Effects

Kim H, Cho SW, Park YJ

Cancer immunotherapy has emerged as a promising therapy for a wide variety of tumors. Immune checkpoint inhibitors including anti cytotoxic T lymphocyte antigen 4 (CTLA-4), programmed death 1 (PD-1) and...
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Immune-related Adverse Events: Overview and Management Strategies for the Use of Immune Checkpoint Inhibitors

Jeung HC, Oh SE, Kim JH

Recent studies on T cell immunology have been instrumental in developing therapies to overcome cancer immune escape, and immune checkpoint inhibitors have emerged as one of the most promising therapeutic...
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Novel application of Influenza A virus-inoculated chorioallantoic membrane to characterize a NP-specific monoclonal antibody for immunohistochemistry assaying

Tu YC, Chen KY, Chen CK, Cheng MC, Lee SH, Cheng IC

Monoclonal antibodies (MAbs) are widely applied in disease diagnoses. Herein, we report a MAb, WF-4, against Influenza A virus nucleoprotein (NP), its broad response with Influenza A virus, and its...
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Current state and outlook for drug repositioning anticipated in the field of ovarian cancer

Kobayashi , Banno K, Kunitomi H, Tominaga E, Aoki D

Ovarian cancer is the seventh most common cancer and the eighth most common cause of cancer mortality in women. Although standard chemotherapy is the established treatment for ovarian cancer, the...
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Primary malignant melanoma of the uterine cervix treated with pembrolizumab after radical surgery: a case report and literature review

Kim MS, Choi CH, Kim TJ, Lee JW, Lee J, Bae DS, Kim BG

Malignant melanoma of the genital tract is a rare disease that is usually diagnosed by chance. When a definite diagnosis is delayed, the prognosis is very poor without standardized treatment....
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Flow-Cytometric Analysis of HNA-2 Expression and Phenotypes Among Thai Blood Donors

Nathalang , Siriphanthong K, Petvises S, Jeumjanya

BACKGROUND: Antibodies specific to human neutrophil antigen (HNA), especially HNA-2, are implicated in various conditions, including neonatal alloimmune neutropenia, febrile non-hemolytic transfusion reactions, and transfusion-related acute lung injury. The distribution...
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Novel strategies in immunotherapy for allergic diseases

Rajakulendran M, Tham EH, Soh JY, Van Bever

Conventional immunotherapy (IT) for optimal control of respiratory and food allergies has been fraught with concerns of efficacy, safety, and tolerability. The development of adjuvants to conventional IT has potentially...
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Flow cytometric immunophenotyping of canine adipose-derived mesenchymal stem cells (ADMSCs) and feline ADMSCs using anti-human antibodies

Ko M, Lee KY, Kim SH, Kim M, Choi JH, Im W, Chung JY

Various trials have been conducted to develop therapies for serious untreatable diseases. Among these, those using stem cells have shown great promise, and adipose-derived mesenchymal stem cells (ADMSCs) are easier...
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Development of a Rapid Diagnostic Test Kit to Detect IgG/IgM Antibody against Zika Virus Using Monoclonal Antibodies to the Envelope and Non-structural Protein 1 of the Virus

Kim YH, Lee J, Kim YE, Chong CK, Pinchemel , Reisdörfer F, Coelho JB, Dias RF, Bae PK, Gusmão ZP, Ahn HJ, Nam HW

We developed a Rapid Diagnostic Test (RDT) kit for detecting IgG/IgM antibodies against Zika virus (ZIKV) using monoclonal antibodies to the envelope (E) and non-structural protein 1 (NS1) of ZIKV....
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Connective Tissue Growth Factor Neutralization Aggravates the Psoriasis Skin Lesion: The Analysis of Psoriasis Model Mice and Patients

Hayakawa K, Ikeda K, Fujishiro , Yoshida Y, Hirai T, Tsushima H, Miyashita , Morimoto S, Suga Y, Takamori K, Ogawa H, Sekigawa I

BACKGROUND: Connective tissue growth factor (CTGF) is a multifunctional cellular protein and playing a role as a central mediator in tissue remodeling and fibrosis. The physiological function of CTGF in...
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Radioimmunotherapy in Head and Neck Cancer

Choi IJ

Radioimmunotherapy (RIT) is a therapy that takes advantage of the “cross-fire” effect of emitted radiation by radionuclides conjugated to tumor-directed monoclonal antibodies (mAb) (including those fragments) or peptides. While RIT...
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