Osteoporosis.  2013 Apr;11(1):9-18.

The Association among Serum Leptin System, Bone Biochemical Markers and Bone Mineral Density Before and After Hormone Therapy

Affiliations
  • 1Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea. kimjg@snu.ac.kr
  • 2Biomedical Research Institute, Seoul National University Hospital, Seoul, Korea.

Abstract


OBJECTIVES
To investigate the relationships between serum leptin, soluble leptin receptor (sLR) and bone mineral density (BMD) and bone biochemical markers and to evaluate association among these factors after hormone therapy (HT) in postmenopausal Korean women.
METHODS
Serum leptin, sLR, biochemical markers, osteoprotegerin (OPG) and soluble receptor activator of NF-kB ligand (sRANKL) were measured by enzyme linked immunosorbent assay in 159 postmenopausal Korean women. The BMD at the lumbar spine (LS) and femoral neck (FN) was determined by dual energy X-ray absorptiometry, and changes of these factors were also measured in 70 postmenopausal women receiving HT.
RESULTS
After adjustment for age and year since menopause, body mass index (BMI) was found to be significantly correlated with leptin (r=0.42, P<0.0001), sLR (r=-0.24, P<0.005), free leptin index (FLI, r=0.47, P<0.0001) and serum OPG was also correlated with serum leptin (r=-0.24, P<0.005) or sLR (r=-0.16, P<0.05). Serum leptin levels and FLI in obese women (BMI>25 kg/m2) were significantly higher than those in women with normal weight, whereas sLR levels were lower in the former women than in the latter women. After HT, serum leptin levels (P<0.005) and FLI (P<0.05) decreased significantly and decreased serum sLR levels (P<0.05) was found only in obese women. The percent changes in BMD at FN after HT were negatively correlated with the changes of sLR after HT.
CONCLUSIONS
Circulating leptin system is not associated with BMD but BMI. Leptin and FLI decrease after HT and the changes of sLR reflects changes in BMD at FN after HT.

Keyword

Biochemical markers; Bone density; Hormone replacement therapy; Leptin

MeSH Terms

Absorptiometry, Photon
Biomarkers
Body Mass Index
Bone Density
Enzyme-Linked Immunosorbent Assay
Female
Femur Neck
Hormone Replacement Therapy
Humans
Leptin
Menopause
NF-kappa B
Osteoprotegerin
Receptors, Leptin
Spine
Leptin
NF-kappa B
Osteoprotegerin
Receptors, Leptin
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