Nutr Res Pract.  2014 Aug;8(4):417-424.

Plasma adipocytokines and antioxidants-status in Korean overweight and obese females with dyslipidemia

Affiliations
  • 1Department of Food Science and Nutrition, Dankook University, 152 Jukjeon-Ro, Suji-Gu, Yongin-Si, Gyeonggi 448-701, Korea. wkkim@dankook.ac.kr
  • 2Department of Food and Nutrition, Eulji University, 553 Sanseong-Daero, Seongnam-Si, Gyeonggi 461-632, Korea.

Abstract

BACKGROUD/OBEJECTIVES: It is hypothesized that obese people with dyslipidemia is more likely to have increased oxidative stress and decreased antioxidant status, in comparison with the controls who were obese without dyslipidemia. Thus, the aims of the present study were to determine the dietary intakes, plasma adipokines, and antioxidative systems between obese with dyslipidemia and obese without dyslipidemia were investigated.
SUBJECTS/METHODS
Female subjects who were between 20 and 55 years old, and whose BMI was 23 or greater were recruited. Subjects who met the criteria of BMI > or = 23, total cholesterol > or = 200 mg/dL, LDL cholesterol > or = 130 mg/dL, and TG > or = 110 mg/dL were categorized Obese with dyslipidemia. Anthropometric measurements and blood biochemical tests were conducted. The diet survey was conducted by a trained dietitian using two days of 24 hour dietary recall. The lipid peroxidation, the plasma total antioxidant capacity (TAC), the activities of antioxidantive enzymes, and various antioxidantive vitamins levels were determined.
RESULTS
Plasma adiponectin and leptin levels were also determined. There were no significant differences for age, Body Mass index (BMI), and body fat (%), waist-size between two groups. Obese with dyslipidemia had significantly high levels of total cholesterol, triglyceride, LDL-cholesterol, the ratio of total cholesterol/HDL-C, and the ratio of HDL-C/LDL-C, respectively. Blood alkaline phosphatase level was statistically different between the two groups (P < 0.05). No statistical significance in dietary intake between two groups was shown. In case of obese with dyslipidemia group, the levels of GSH-Px (P < 0.05) and catalase (P < 0.05) as well as adjusted blood retinol (P < 0.05) and tocopherol level (P < 0.05) were significantly low. However, the plasma concentration of leptin was significantly high (P < 0.05).
CONCLUSIONS
Obesity with dyslipidemia was shown to have high arthtrogenic index, depleted antioxidant status, and higher blood leptin levels which suggest higher risks of oxidative stress and cardiovascular diseases.

Keyword

Obese; dyslipidemia; dietary intake; antioxidant; leptin

MeSH Terms

Adipokines*
Adiponectin
Adipose Tissue
Alkaline Phosphatase
Body Mass Index
Cardiovascular Diseases
Catalase
Cholesterol
Cholesterol, LDL
Diet Surveys
Dyslipidemias*
Female
Humans
Leptin
Lipid Peroxidation
Nutritionists
Obesity
Overweight*
Oxidative Stress
Plasma*
Tocopherols
Triglycerides
Vitamin A
Vitamins
Adipokines
Adiponectin
Alkaline Phosphatase
Catalase
Cholesterol
Cholesterol, LDL
Leptin
Tocopherols
Vitamin A
Vitamins

Figure

  • Fig. 1 The plasma concentrations of adiponectin in subjects. Subjects were divided into two groups; obese without dyslipidemia is the control group and obese with dyslipidemia is the experimental group who met the criteria of BMI ≥ 23, total cholesterol ≥ 200 mg/dL, LDL cholesterol ≥ 130 mg/dL, and TG ≥ 110 mg/dL. Each bar represents the mean ± S.D. NS stands for not significant difference between two group, which was determined by t-test.

  • Fig. 2 The plasma concentrations of leptin in subjects. Subjects were divided into two group; obese without dyslipidemia is the control group and obese with dyslipidemia is the experimental group who met the criteria of BMI ≥ 23, total cholesterol ≥ 200 mg/dL, LDL cholesterol ≥ 130 mg/dL, and TG ≥ 10 mg/dL. Each bar represents the mean ± S.D. Significant difference (*P < 0.05) between the two group was determined by t-test.


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