Nutr Res Pract.  2012 Feb;6(1):9-15.

The effects of Angelica keiskei Koidz on the expression of antioxidant enzymes related to lipid profiles in rats fed a high fat diet

• Kim E
• Choi J
• Yeo I

Abstract

This study was performed to examine the feeding effects of Angelica keiskei Koidz (AK) and its processed products on serum, liver, and body fat content and the expression of antioxidant genes in rats fed a high fat diet. AK and its processed products were added at 3-5% to a high fat diet and fed to adult rats for 6 weeks. In experiment 1 (EXP 1), the rats were fed with one of six diets including a control diet (normal fat), high fat diet (HF), and HF + AK additives groups (four groups). In experiment 2 (EXP 2), the rats were separated into three groups of HF, HF + AK whole leaves, and HF + fermented juice (FS) + squeeze (SA). Body weight was not different among the groups in either experiment. The liver weight was lower in the FS and SA groups compared to that in the other groups (P < 0.05). Serum luteolin was higher in the AK and processed products groups compared to that in the HF group (P < 0.05). Gene expression of the antioxidative enzymes catalase and glutathione-s-reductase in the liver was higher in the AK processed products group than that in the other groups (P < 0.05). The results suggest that the intake of AK and its processed products increased the expression of antioxidant enzymes in animals fed a high fat diet, reduced hepatic cholesterol content, and increased the effective absorption of luteolin.

Keyword

Angelica keiskei Koidz; luteolin; high fat diet; antioxidation enzymes; lipid metabolism

MeSH Terms

Absorption
Adipose Tissue
Adult
Angelica
Animals
Body Weight
Catalase
Cholesterol
Diet
Diet, High-Fat
Gene Expression
Humans
Lipid Metabolism
Liver
Luteolin
Rats
Catalase
Cholesterol
Luteolin

Figure

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  Fig. 1 Serum luteolin concentrations in rats fed the experimental diets for 6 weeks (EXP 1). Values are mean ± standard deviation (n = 6-8). HF, high fat diet; AK, Angelica keiskei; ES, solution extracted from AK; FS, fermented ES; SA, solid squeezed from AK. Bars with different letters are statistically different ((P < 0.05).

• 

  Fig. 2 Serum luteolin concentrations in rats fed the experimental diets for 6 weeks (EXP 2). Values are mean ± standard deviation (n = 6-8). HF, high fat diet; AK, Angelica keiskei; ES, solution extracted from AK; SA, solid squeezed from AK. Bars with different letters are statistically different (P < 0.05).

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