Lab Med Online.  2012 Jul;2(3):166-169.

Autoimmune Hemolytic Anemia after Aplastic Crisis due to Parvovirus B19 Infection in a Patient with Hereditary Spherocytosis

  • 1Department of Laboratory Medicine, Inje University College of Medicine, Busan, Korea.


Hereditary spherocytosis (HS) is a genetic disorder characterized by the production and destruction of spherocytes due to a deficiency of red cell membrane cytoskeletal proteins, resulting in the clinical presentation of chronic hemolytic anemia. This disease can be accompanied by an aplastic crisis due to parvovirus B19 infection. Parvovirus B19 infection causes diseases such as erythema infectiosum and arthritis, and can also trigger various autoimmune diseases, including autoimmune hemolytic anemia (AIHA). Here, we report a rare case of AIHA developing 3 months after an aplastic crisis due to parvovirus B19 infection in an 11-year-old boy with HS and provide the relevant literature review.


Hereditary spherocytosis; Parvovirus B19; Autoimmune hemolytic anemia

MeSH Terms

Anemia, Hemolytic
Anemia, Hemolytic, Autoimmune
Autoimmune Diseases
Cell Membrane
Cytoskeletal Proteins
Erythema Infectiosum
Spherocytosis, Hereditary
Cytoskeletal Proteins


  • Fig. 1 Diagram of hemoglobin (Hb) and reticulocyte count (Reti) showing disease course during autoimmune hemolytic anemia following aplastic crisis due to parvovirus B19 infection. DAT represents direct antiglobulin test.


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