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Inorganic lead (Pb)- and mercury (Hg)-induced neuronal cell death involves cytoskeletal reorganization

Choi WS, Kim SJ, Kim JS

Inorganic lead and mercury are widely spread xenobiotic neurotoxicants threatening public health. The exposure to inorganic lead and mercury results in adverse effects of poisoning including IQ deficit and peripheral...
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Endodermal sinus tumor: immunophenotypic expression of a carcinoma

Chung J, Gong G, Cho J, Choe G, Yu E, Lee I

A series of five endodermal sinus tumors was studied for their cytoskeletal and other phenotypic markers. They included 2 ovarian, 2 testicular, and 1 inguinal tumors. The cytoskeletal expression was...
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New Perspectives of Dyrk1A Role in Neurogenesis and Neuropathologic Features of Down Syndrome

Park J, Chung KC

Down syndrome (DS) is one of the most common genetic disorders accompanying with mental retardation, cognitive impairment, and deficits in learning and memory. The brains with DS also display many...
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Tyrosine phosphorylation of paxillin may be involved in vascular smooth muscle contraction

Fang LH, Cho KS, Lee SJ, Ahn HY

  • KMID: 1580807
  • Korean J Physiol Pharmacol.
  • 2000 Jun;4(3):211-217.
Paxillin is a regulatory component of the complex of cytoskeletal proteins that link the actin cytoskeleton to the plasma membrane. However, the role of paxillin during smooth muscle contraction is unclear. We investigated...
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Localization of cytoskeletal proteins in Pneumocystis carinii by immuno-electron microscopy

Yu JR, Pyon JK, Seo M, Jung BS, Cho SR, Lee SH, Hong ST

Pneumocystis carinii causes serious pulmonary infection in immunosuppressed patients. This study was undertaken to observe the cytoskeletal proteins of P. carinii by immuno-electron microscopy. P. carinii infection was experimentally...
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Loss of PTEN Expression in Primary Lung Cancer

Roh MS

  • KMID: 2275559
  • Korean J Pathol.
  • 2002 Oct;36(5):286-291.
BACKGROUND: The phosphatase and tensin homolog deleted on chromosome 10 (PTEN) gene, a candidate tumor suppressor, is localized to chromosome 10q23 and shares extensive homology with cytoskeletal proteins auxilin and...
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Autoimmune Hemolytic Anemia after Aplastic Crisis due to Parvovirus B19 Infection in a Patient with Hereditary Spherocytosis

Song SA, Lee MY, Kim SH, Lee JY, Oh SH, Shin JH, Kim HR, Jun KR, Lee JN

  • KMID: 2312200
  • Lab Med Online.
  • 2012 Jul;2(3):166-169.
Hereditary spherocytosis (HS) is a genetic disorder characterized by the production and destruction of spherocytes due to a deficiency of red cell membrane cytoskeletal proteins, resulting in the clinical presentation...
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The Effect of PLCgamma1 Pleckstrin Homology Domain on Il - 6 - induced B Cell Response

Pyun KH, Choi IP, Han MY, Yoon SY, Song HK, Lee HY

  • KMID: 1548377
  • Korean J Immunol.
  • 1997 Dec;19(4):525-532.
The pleckstrin homology (PH) domain is a protein module of approximately 100 amino acids, that has been found in signaling molecules, including serinelthreonine kinase, GTPase-activating protein, phospholipase, and some cytoskeletal...
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Neurofilament Protein Subtype Expression in Neuronal Migration Disorders

Oh HS, Choi YD, Kim HJ, Lee KH, Kim MK, Woo YJ, Kim JH, Lee MC

  • KMID: 1979370
  • Korean J Pathol.
  • 2003 Dec;37(6):413-420.
BACKGROUND: Neuronal migration disorder (NMD) is one of the causes of medically intractable epilepsy. As neurosurgical treatments for medically intractable epilepsy have expanded recently, precise histopathologic diagnosis is required. Histopathologic...
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Ezrin is an Essential Marker for Metastasis of Gynecologic Cancer

Choi SD

  • KMID: 2365471
  • J Korean Soc Menopause.
  • 2012 Aug;18(2):81-93.
Ezrin, a membrane cytoskeleton linking protein, is a member of ezrin/radixin/moesin (ERM) that regulates cell shape, motility and cell to cell interaction via linking the contractile elements of the cell...
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Subcellular Distribution of Microtubule in Artificially Induced Senescent PC12 Cells

Lee E, Oh CS, Shin DH, Lee YS

  • KMID: 2338530
  • J Korean Geriatr Soc.
  • 2006 Dec;10(4):278-284.
Background: Since recent reports showed the possibility that cytoskeletal proteins, which were known to be exclusively within the cytoplasm, might play a role in the re-distribution of the intranuclear chromatin...
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NLRP6 as a Negative Regulator of Innate Immunity

Manzoor Z, Koh YS

Nucleotide-binding and oligomerization domain (NOD)-like receptors (NLRs) play important role in immune responses by regulating nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB), type I interferon and inflammasomes. Nod-like receptor...
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Proteomic Profiling of Human Small Cell Lung Cancer Cell Line NCI-H211

Cho HY, Kim MK, Yoo YD, Ahn MJ, Jang JS

  • KMID: 1972869
  • Cancer Res Treat.
  • 2003 Dec;35(6):489-496.
PURPOSE: Small cell lung cancer is one of the major causes of death from cancer worldwide. To explore the expressions of global protein in small cell lung cancer cells, a...
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Mechanisms Underlying Trabecular Meshwork Cell Death Caused by Mutant Myocilin Expression

Lim DH, Sohn S, Kim TE, Kee C

PURPOSE: To determine whether the expression of mutant myocilin can lead to death of human trabecular meshwork (HTM) cells and to determine whether the mechanism by which this occurs is...
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RET Fusion Genes in Korean Non-Small Cell Lung Cancer

Yoo SS, Jin G, Jung HJ, Hong MJ, Choi JE, Jeon HS, Lee SY, Lim JO, Park JY

Recently, rearranged during transfection (RET) fusions have been identified in approximately 1% of non-small cell lung cancer (NSCLC). To know the prevalence of RET fusion genes in Korean NSCLCs, we...
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Pyrin Domain (PYD)-containing Inflammasome in Innate Immunity

Hong S, Park S, Yu JW

Inflammasome is a cytosolic multiprotein complex to activate caspase-1 leading to the subsequent processing of inactive pro-interleukin-1-beta (Pro-IL-1beta) into its active interleukin-1 beta (IL-1beta) in response to pathogen- or danger-associated...
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Endothelial cells from the rat aorta in culture

Kim JY

  • KMID: 2092645
  • Korean J Anat.
  • 1998 Feb;31(1):105-116.
Endothelial cells were isolated from the intima of Sprague-Dawley rat aorta with 0.2% collagenase solution and cultured in MCDB 131 medium. All endothelial cells regardless of passages and the...
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Quantitative Proteomic Analysis Reveals Impaired Axonal Guidance Signaling in Human Postmortem Brain Tissues of Chronic Traumatic Encephalopathy

Bi B, Choi HP, Hyeon SJ, Sun S, Su N, Liu Y, Lee J, Kowall NW, McKee AC, Yang JH, Ryu H

Chronic traumatic encephalopathy (CTE) is a distinct neurodegenerative disease that associated with repetitive head trauma. CTE is neuropathologically defined by the perivascular accumulation of abnormally phosphorylated tau protein in the...
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Proteomics Analysis for Helicobacter pylori-infected Gastric Mucosa

Kang HS, Hong SN, Park HR, Kwon MJ, Lee JH, Kim JJ

BACKGROUND/AIMS: Helicobacter pylori infection is linked to the development of gastric cancer. H. pylori-associated gastric inflammation is considered to be the first important step in the histogenesis of such neoplasia....
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Particulate Air Pollutants and Airway Inflammation

Jang AS, Park CS, Choi IS

Particulate air pollutants emanating from traffic and various industries are related to allergic airway disorders including asthma. Particulate air pollutants inhalation directly induces lung inflammation to allergens or respiratory viral...
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