J Korean Pediatr Soc.  2003 Nov;46(11):1139-1142.

Aplastic Crisis Secondary to Parvovirus B19 Infection

Affiliations
  • 1Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Korea. kdk7016@hanmail.net

Abstract

Human parvovirus(HPV) B19 infection causes erythema infectiosum in children, sometimes red cell aplastic crisis with hemolytic anemia and chronic bone marrow failure in immunocompromised hosts. HPV B19 is directly cytotoxic for erythroid progenitor cells and inhibits erythropoiesis. Infrequently, HPV B19 inhibits hematopoiesis of three cell lineages and causes transient pancytopenia in patients with hemolytic disorders. We report three patients with hereditary spherocytosis who developed transient aplastic crisis. A HPV B19 infection was confirmed by IgM anti-B19 parvovirus titers and characteristic findings of bone marrow examination as the causative agent associated with severe pancytopenia. Three patients recovered spontaneously after a short period of supportive care with red cell transfusions and intravenous immunoglobulin.

Keyword

Aplastic Crisis; Parvovirus B19; Hereditary spherocytosis

MeSH Terms

Anemia, Hemolytic
Bone Marrow
Bone Marrow Examination
Cell Lineage
Child
Erythema Infectiosum
Erythroid Precursor Cells
Erythropoiesis
Hematopoiesis
Humans
Immunocompromised Host
Immunoglobulin M
Immunoglobulins
Pancytopenia
Parvovirus*
Immunoglobulin M
Immunoglobulins
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