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Associations of Plasma Neutrophil Gelatinase-associated Lipocalin, Anemia, and Renal Scarring in Children with Febrile Urinary Tract Infections

Lee JH, Yim HE, Yoo KH

BACKGROUND: Neutrophil gelatinase-associated lipocalin (NGAL), a bacteriostatic agent, is known to inhibit erythropoiesis leading to anemia. We aimed to investigate the associations of NGAL, anemia, and renal scarring in children...
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New Oral Agent for Treatment of Anemia in Patient with Chronic Kidney Disease: Prolyl Hydroxylase Inhibitor

Na K

Hypoxia inducible factor (HIF)-stabilizers are being developed for the renal anemia treatment. This small molecules inhibit prolyl hydroxylase domain (PHD)-containing enzymes, causing HIF activation instead of degradation under the state...
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Treatment of renal anemia: Erythropoiesis stimulating agents and beyond

Biggar P, Kim GH

Anemia, complicating the course of chronic kidney disease, is a significant parameter, whether interpreted as subjective impairment or an objective prognostic marker. Renal anemia is predominantly due to relative erythropoietin...
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Management of Blood Loss in Hip Arthroplasty: Korean Hip Society Current Consensus

Song JH, Park JW, Lee YK, Kim IS, Nho JH, Lee KJ, Park KK, Kim Y, Park JH, Han SB

The volume of hip arthroplasty is stiffly increasing because of excellent clinical outcomes, however it has not been shown to decrease the incidence of transfusions due to bleeding related to...
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Regulation of the embryonic erythropoietic niche: a future perspective

Yumine A, Fraser ST, Sugiyama D

The production of red blood cells, termed erythropoiesis, occurs in two waves in the developing mouse embryo: first primitive erythropoiesis followed by definitive erythropoiesis. In the mouse embryo, both primitive...
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Genetically Engineered In Vitro Erythropoiesis

Geiler C, Andrade I, Clayton A, Greenwald

BACKGROUND: Engineered blood has the greatest potential to combat a predicted future shortfall in the US blood supply for transfusion treatments. Engineered blood produced from hematopoietic stem cell (HSC) derived...
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Recombinant Human Erythropoietin Therapy for a Jehovah's Witness Child With Severe Anemia due to Hemolytic-Uremic Syndrome

Woo DE, Lee JM, Kim YK, Park YH

Patients with hemolytic-uremic syndrome (HUS) can rapidly develop profound anemia as the disease progresses, as a consequence of red blood cell (RBC) hemolysis and inadequate erythropoietin synthesis. Therefore, RBC transfusion...
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Hematopoietic effect of deer antler extract fermented by Bacillus subtilis on murine marrow cells

Park Y, Choi HS, Lee HS, Suh HJ

BACKGROUND/OBJECTIVES: We examined the chemical composition and the effect of fermented deer antler on hematopoietic factors in bone marrow cells. MATERIALS/METHODS: For the preparation of fermented deer antler extract (FAB), fermentation...
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The usefulness of soluble transferrin receptor in the diagnosis and treatment of iron deficiency anemia in children

Yoon SH, Kim DS, Yu ST, Shin SR, Choi DY

PURPOSE: Soluble transferrin receptor (sTfR) is a truncated extracellular form of the membrane transferrin receptor produced by proteolysis. Concentrations of serum sTfR are related to iron status and erythropoiesis in...
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Microarray Analysis of Gene Expression Reveals that Cyclo-oxygenase-2 Gene Therapy Up-regulates Hematopoiesis and Down-regulates Inflammation During Endochondral Bone Fracture Healing

Lau KH, Popa NL, Rundle CH

BACKGROUND: Cyclo-oxygenase-2 (Cox-2) is an inflammatory mediator that is necessary for the tissue repair, including bone fracture healing. Although the application of Cox-2 gene therapy to a murine closed femoral...
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A randomized crossover study of single biweekly administration of epoetin-alpha compared with darbepoetin-alpha in chronic kidney disease patients not receiving dialysis

Na HY, Lee YK, Shin SK, Yang DH, Cheon W, Park JH, Lee JH, Song JO, Jo YI

BACKGROUND: Recent evidence demonstrates that high doses of epoetin-alpha (EPO-alpha) can be administrated at extended intervals, despite its relatively short serum half-life. However, no prospective randomized trials on the effects...
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Exogenous c-Myc Blocks Differentiation and Improves Expansion of Human Erythroblasts In vitro

Geiler C, Andrade I, Greenwald

BACKGROUND: Engineered blood has the greatest potential to combat a predicted future shortfall in the blood supply for transfusion treatment. The production of red blood cells from hematopoietic stem cells...
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Studies on In Vivo Function of Peroxiredoxins in Knockout Mice

Yu DY

Peroxiredoxins (Prxs) are a family of antioxidant proteins that reduce peroxide levels by using reducing agents such as thioredoxin. These proteins were characterized to have a number of cellular functions,...
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Role of hepcidin in the pathophysiology and diagnosis of anemia

D'Angelo G

This review summarizes the central role of hepcidin in the iron homeostasis mechanism, the molecular mechanism that can alter hepcidin expression, the relationship between hepcidin and erythropoiesis, and the pathogenetic...
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Effects of Serotonin on Erythropoietin Expression in Mouse Hippocampus

Choi M, Son H

Serotonin (5-hydroxytryptamine, 5-HT), a monoamine neurotransmitter, regulates neurological functions such as mood, sleep, and appetite. Erythropoietin (EPO) is well known for erythropoiesis but has recently emerged as a therapeutic agent...
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Relationship between Bone Mineral Density, Erythropoiesis, and Calcium-Phosphorus-Parathyroid Hormone Status in End-stage Renal Disease Patients

Oh YJ, Hong S, Min K, Song JH, Lee SY, Kim SH, Nam M, Kim YS

  • KMID: 2255857
  • Korean J Bone Metab.
  • 2011 Nov;18(2):93-99.
OBJECTIVES: Abnormal bone turnover and mineralization is the characteristic of the end-stage renal disease (ESRD) patients receiving dialysis treatment. Reduced bone mineral density (BMD) has been reported in ESRD patients...
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Hemoglobin Variability Associated with Different Erythropoiesis Stimulating Agents in Hemodialysis Patients

Park SK, Hwang KS, Park JS, Lee CH, Kang CM, Kim GH

  • KMID: 2307154
  • Korean J Nephrol.
  • 2011 Jan;30(1):41-47.
PURPOSE: This study was undertaken to examine whether differences exist in the hemoglobin variability according to the types of erythropoiesis stimulating agent (ESA) in hemodialysis (HD) patients. METHODS: Clinical data were...
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Hemoglobin Variability Associated with Erythropoiesis Stimulating Agents

Bae EH

  • KMID: 2307149
  • Korean J Nephrol.
  • 2011 Jan;30(1):1-3.
No abstract available.
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Lupus Cystitis and Azathioprine-iIduced Pure Red Cell Aplasia in a Patient with Systemic Lupus Erythematosus

Koo TY, Kim HJ, Kim KM, Oh DK, Park GB, Lee SK

  • KMID: 2307142
  • Korean J Nephrol.
  • 2011 Jan;30(1):102-106.
We report a case of lupus cystitis as the manifestation of lupus flare, and pure red cell aplasia resulting from the use of azathioprine in a patient with systemic lupus...
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Iron Status According to Serum Selenium Concentration and Physique in Young Female Adults

Lee O, Chung Y, Moon J

Se and Fe are trace minerals acting as antioxidant scavenging free radicals. Iron deficiency is the most frequently reported nutritional deficiency in females. Body iron status are known to be...
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