Lab Anim Res.  2016 Jun;32(2):79-86. 10.5625/lar.2016.32.2.79.

Reference values of clinical pathology parameters in cynomolgus monkeys (Macaca fascicularis) used in preclinical studies

• Park HK
• Cho JW
• Lee BS
• Park H
• Han JS
• Yang MJ
• Im WJ
• Park DY
• Kim WJ
• Han SC
• Kim YB

• KMID: 2309080
• DOI: http://doi.org/10.5625/lar.2016.32.2.79

Abstract

Nonhuman primates are increasingly used in biomedical research since they are highly homologous to humans compared to other rodent animals. However, there is limited reliable reference data of the clinical pathology parameters in cynomolgus monkeys, and in particular, only some coagulation and urinalysis parameters have been reported. Here, we reported the reference data of clinical chemical, hematological, blood coagulation, and urinalysis parameters in cynomolgus monkeys. The role of sex differences was analyzed and several parameters (including hematocrit, hemoglobin, red blood cell, blood urea nitrogen, total bilirubin, alkaline phosphatase, creatinine kinase, gamma-glutamyl tranferase, and lactate dehydrogenase) significantly differed between male and female subjects. In addition, compared to previous study results, lactate dehydrogenase, creatinine kinase, and aspartate aminotransferase showed significant variation. Interstudy differences could be affected by several factors, including age, sex, geographic origin, presence/absence of anesthetics, fasting state, and the analytical methods used. Therefore, it is important to deliberate with the overall reference indices. In conclusion, the current study provides a comprehensive and updated reference data of the clinical pathology parameters in cynomolgus monkeys and provides improved assessment criteria for evaluating preclinical studies or biomedical research.

Keyword

Cynomolgus monkey; clinical chemistry; hematology; blood coagulation; urinalysis

MeSH Terms

Alkaline Phosphatase
Anesthetics
Animals
Aspartate Aminotransferases
Bilirubin
Blood Coagulation
Blood Urea Nitrogen
Chemistry, Clinical
Creatinine
Erythrocytes
Fasting
Female
Hematocrit
Hematology
Humans
L-Lactate Dehydrogenase
Lactic Acid
Macaca fascicularis*
Male
Pathology, Clinical*
Phosphotransferases
Primates
Reference Values*
Rodentia
Sex Characteristics
Urinalysis
Alkaline Phosphatase
Anesthetics
Aspartate Aminotransferases
Bilirubin
Creatinine
L-Lactate Dehydrogenase
Lactic Acid
Phosphotransferases

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