Lab Anim Res.  2021 Jun;37(2):112-115. 10.1186/s42826-021-00092-2.

A comparative study on intraocular pressure under various anesthetics in cynomolgus monkeys (Macaca fascicularis)

Affiliations
  • 1Biotoxtech, 53 Yeongudanji-ro, Ochang-eup, Chungcheongbuk-do, South Korea
  • 2Korea Institute of Toxicology, 30 Haekhak 1-gil, Jeongeup, Jeollabuk-do, South Korea

Abstract

Background
Nonhuman primates (NHPs) are superior model for ocular research due to its morphological and physiological similarities with humans. Thus, the effect of four different anesthetic combinations [ketamine (10 mg/ kg), ketamine + xylazine (7 + 0.6 mg/kg), zoletil (4 mg/kg), and zoletil + xylazine (4 + 0.2 mg/kg)] on intraocular pressure (IOP) was determined in cynomolgus monkeys.
Results
The administration of ketamine + xylazine or zoletil + xylazine resulted in lower IOP compared to ketamine or zoletil alone. Moreover, the IOP in male monkeys was higher than in females. The difference between the right and left eye was not found.
Conclusions
Anesthetics affected the IOP, and gender differences should be considered when measuring the IOP of nonhuman primates (NHPs).

Keyword

Anesthetics; Cynomolgus monkey; Intraocular pressure; TonoVet™
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