Korean J Neurogastroenterol Motil.  2007 Dec;13(2):138-145.

Effect of Mosapride Citrate and Combined Treatment with Ondansetron on Postoperative Ileus in Rats

Affiliations
  • 1Department of Internal Medicine and Digestive Disease Research Institute, Wonkwang University School of Medicine, Iksan, Korea.
  • 2Department of Surgery, Wonkwang University School of Medicine, Iksan, Korea.
  • 3Department of Physiology and Institute of Wonkwang Medical Science, Wonkwang University School of Medicine, Iksan, Korea. lmy6774@wku.ac.kr

Abstract

BACKGROUND/AIMS: Postoperative ileus (POI) is a transient impairment of gastrointestinal motility after surgery. The mechanisms of POI are not completely understood, but it has been accepted that an activation of inhibitory neural reflex pathways was most important. Cisapride have been demonstrated to improve POI, but it was withdrawn from market due to cardiac toxicity. The purpose of this study was to investigate whether mosapride citrate (mosapride) and combined use of ondansetron could prevent POI.
METHODS
Male Sprague-Dawley rats were used. Experimental groups were Control, POI only, POI+20 mg/kg mosapride, POI+mosapride with 0.8 mg/kg ondansetron, and POI+mosapride with 4 mg/kg ondansetron. POI was induced by massage of cecum under isoflurane anesthesia. Evans blue was fed after 1hour from operation. Gastric emptying (GE) and small intestinal transit (SIT) were measured after 30 min.
RESULTS
GE and SIT significantly delayed in POI only group than control. Mosapride improved the delayed GE and SIT. The 0.8 mg ondansetron group showed more improved SIT than mosapride only group. The 4 mg ondansetron group showed more delayed GE and SIT than mosapride only group.
CONCLUSIONS
Mosapride have beneficial effect on POI and it was enhanced by low dose ondansetron, but interrupted by high dose ondansetron.

Keyword

Gastric emptying; Mosapride citrate; Ondansetron; Postoperative Ileus; Small intestinal transit; Serotonin

MeSH Terms

Anesthesia
Animals
Cecum
Cisapride
Citric Acid*
Evans Blue
Gastric Emptying
Gastrointestinal Motility
Humans
Ileus*
Isoflurane
Male
Massage
Ondansetron*
Rats*
Rats, Sprague-Dawley
Reflex
Serotonin
Cisapride
Citric Acid
Evans Blue
Isoflurane
Ondansetron
Serotonin
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