Korean J Med.  2011 Jan;80(1):122-127.

Successful Treatment with Methotrexate and Azathioprine of Panniculitis in a Patient with Dermatomyositis: Case Report and Review of the Literature

Affiliations
  • 1Department of Rheumatology, Chonnam National University Medical School, Gwangju, Korea. shinseok@chonnam.ac.kr
  • 2Department of Dermatology, Chonnam National University Medical School, Gwangju, Korea.

Abstract

Dermatomyositis is an autoimmune disease wherein autoantibodies and immune complexes cause non-suppurative inflammation in skin and muscle. Although the skin lesions of this disease are well known, the clinical and pathological features of subcutaneous fat lesions remain uncharacterized. Since Weber (1924) reported the development of panniculitis in a patient with dermatomyositis, 23 subsequent cases have been reported. Here, we present the case of a woman who had been diagnosed with dermatomyositis 7 years previously, and presented with diffuse, painful, indurated nodules on her face and upper limbs. A skin biopsy allowed us to diagnose these nodules as panniculitis. The patient was initially treated with high doses of prednisolone and methotrexate. She responded inadequately to these medications, so azathioprine was added to the regimen. The skin lesions subsequently improved and the patient has remained disease-free for 1 year. Here, we present the clinical profile of this patient and review the relevant literature.

Keyword

Dermatomyositis; Panniculitis; Methotrexate; Azathioprine

MeSH Terms

Antigen-Antibody Complex
Autoantibodies
Autoimmune Diseases
Azathioprine
Biopsy
Dermatomyositis
Female
Humans
Inflammation
Methotrexate
Muscles
Panniculitis
Prednisolone
Skin
Subcutaneous Fat
Upper Extremity
Antigen-Antibody Complex
Autoantibodies
Azathioprine
Methotrexate
Prednisolone
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