Korean J Hematol.  2007 Sep;42(3):181-196. 10.5045/kjh.2007.42.3.181.

Cord Blood-Current Status and Perspective

• Lee YH

• KMID: 2305193
• DOI: http://doi.org/10.5045/kjh.2007.42.3.181

Abstract

Umbilical cord blood (CB) is increasingly used as a source of stem cells to repopulate bone marrow in the treatment of life-threatening diseases in children and adults. I review the relationship between the placenta and circulating CB stem cells for hematopoiesis, the clinical results of cord blood stem cell transplantation, and I particularly emphasizethe criteria of CB donor choice. The scientific progress for the use of CB has resulted in the organization of CB banks all over the world. I also review the status of CB banks and networking systems worldwide as recipients of government-based political support.

Keyword

Cord blood; Stem cell transplantation; Cord blood bank; Policy

MeSH Terms

Adult
Bone Marrow
Child
Cord Blood Stem Cell Transplantation
Fetal Blood
Hematopoiesis
Humans
Placenta
Stem Cell Transplantation
Stem Cells
Tissue Donors

Figure

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  Fig. 1 Feto-placental circulation (from Biology in Cornell University, Fall 2007).

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  Fig. 2 Cytokine production from placenta and interaction with hematopoietic stem cells in fetal circulation.

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  Fig. 3 Number of cord blood stem cell transplantation in Korea.

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  Fig. 4 The structure of organization of FACT.

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