Korean J Dermatol.
2007 May;45(5):471-476.
Two Cases of Hemophagocytic Lymphohistiocytosis Following Kikuchi's Disease
- Affiliations
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- 1Department of Dermatology, College of Medicine, Cheju National University, Jeju, Korea. rulid@cheju.ac.kr
Abstract
- Kikuchi's disease is a benign, self-limiting, acute, necrotizing lymphadenitis predominantly occurring in young women in Asia. Hemophagocytic lymphohistiocytosis (HLH), previously known as hemophagocytic syndrome, describes the pathologic phenomenon of activated macrophages engulfing erythrocytes, leukocytes, platelets and their precursor cells. HLH, frequently associated with infection, malignancy or autoimmune disease, runs a potentially fatal course. To my knowledge, there are very few reports of HLH preceded by Kikuchi's disease. I report two cases of HLH following Kikuchi's disease.
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