Korean J Otorhinolaryngol-Head Neck Surg.  2011 Dec;54(12):859-861. 10.3342/kjorl-hns.2011.54.12.859.

A Case of Kikuchi's Disease Associated with Hemophagocytic Syndrome

• Kim HJ
• Park JY
• Chung SM
• Kim HS

• KMID: 2277288
• DOI: http://doi.org/10.3342/kjorl-hns.2011.54.12.859

Abstract

Kikuchi's disease and hemophagocytic syndrome have the clinical similarity in initial presentations, but present different clinical course and prognosis. Kikuchi's disease usually have a self-limiting clinical course, but hemophagocytic syndrome can be fatal. It is important to make differential diagnoses and treat properly. We report a case of 18 year old boy who was admitted to the hospital with two weeks history of fever and progressive cervical lymph node swelling. Cervical lymph node biopsy showed the typical necrotizing lymphadenitis of Kikuchi's disease. There were signs of histiocytosis and hemophagocytic phenomenon in the bone marrow. The etiology, treatment, and prognosis of Kikuchi's disease with hemophagocytic syndrome are discussed.

Keyword

Histiocytic necrotizing lymphadenitis; Hemophagocytic syndrome

MeSH Terms

Biopsy
Bone Marrow
Diagnosis, Differential
Fever
Histiocytic Necrotizing Lymphadenitis
Histiocytosis
Lymph Nodes
Lymphadenitis
Lymphohistiocytosis, Hemophagocytic
Prognosis