Korean J Dermatol.  2008 Feb;46(2):264-267.

A Case of Precursor B-cell Lymphoblastic Lymphoma Misdiagnosed as Rosacea

• Han EC
• Kim DY
• Chung JY
• Chung HJ
• Chung KY

Abstract

Precursor B-cell lymphoblastic lymphoma is a rare type of non-Hodgkin's lymphoma seen exclusively in children and young adults. The neoplasm is rare in old age. We report a case of a 58-year-old male, who presented with variable-sized, erythematous to brownish papules and plaques on the scalp and face. There were no other symptoms. Pathological examination showed non-specific, sparse superficial and deep perivascular lymphocyte infiltration. We diagnosed the condition as rosacea and prescribed 100 mg of minocycline per day for 10 days. When he was seen 10 days later, his skin lesions were aggravated and re-biopsy was completed. Histopathology revealed diffuse infiltrates of small to medium-sized lymphoid cells with blastic nuclear chromatin and a high mitotic rate. Immunohistochemical study showed that infiltrated lymphoid cells were precursor B-cell type. Physical examination and staging work-up revealed extensive involvement of lymphoma in bilateral kidney, heart, pancreas, axial and proximal appendicular bones, scalp and cervical lymph node. The patient is being treated with combination chemotherapy.

Keyword

Precursor B-cell lymphoblastic lymphoma

MeSH Terms

Child
Chromatin
Drug Therapy, Combination
Heart
Humans
Kidney
Lymph Nodes
Lymphocytes
Lymphoma
Lymphoma, Non-Hodgkin
Male
Middle Aged
Minocycline
Pancreas
Physical Examination
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma
Precursor Cells, B-Lymphoid
Rosacea
Scalp
Skin
Young Adult
Chromatin
Minocycline