Korean J Dermatol.
2012 Dec;50(12):1060-1063.
Cutaneous Extramedullary Hematopoiesis in Idiopathic Myelofibrosis
- Affiliations
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- 1Department of Dermatology, School of Medicine, Kyung Hee University, Seoul, Korea. crhaw@khmc.or.kr
Abstract
- Extramedullary hematopoiesis is commonly seen in the liver, spleen and lymph nodes, but cutaneous extramedullary hematopoiesis (CEH) is very rare. CEH affects mainly children with intrauterine viral or hematologic disorders and rare manifestation of chronic myeloproliferative processes in adults. Idiopathic myelofibrosis (IM) is a chronic myeloproliferative disorder and some cases of IM have extramedullary hematopoiesis. IM is characterized by the proliferation of the endothelial cells and fibroblasts in the bone marrow, resulting in disruption of bone marrow, with subsequent migration and proliferation of the hematopoietic stem cells in other organs. We report a very rare case of cutaneous extramedullary hematopoiesis in a 74-year-old male with IM.
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