Korean J Biol Psychiatry.
2008 Nov;15(4):288-296.
No Association between Val108/158Met Polymorphism on Catechol-O-Methyl Transferase(COMT) Gene and Smooth Pursuit Eye Movement(SPEM) Abnormality in Korean Schizophrenia Patients
- Affiliations
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- 1Department of Neuropsychiatry, College of Medicine, Soonchunhyang University, Seoul, Korea.
- 2Keyo Hospital, Euiwang, Korea.
- 3Jinju Mental Hospital, Jinju, Korea.
- 4Department of Biomedical Engineering, Yonsei University, Wonju, Korea. garakman@naver.com
- 5SNP Genetics, Seoul, Korea.
- 6Department of Life Science, Sogang University, Seoul, Korea.
Abstract
OBJECTIVES
We investigated the association of Val108/158Met polymorphism on catechol-O-methyl transferase(COMT) gene with smooth pursuit eye movement(SPEM) abnormality in Korean schizophrenia patients.
METHODS
We measured SPEM in 217 Korean schizophrenia patients(male 116, female 101) and divided them into two groups, one was a good SPEM function group and the other was a poor SPEM function group. Then we analyzed Val108/158Met polymorphism on COMT gene. We compared the differences of genotype and allele distributions of the polymorphism on COMT gene between the two groups.
RESULTS
The natural logarithm value of signal/noise ratio(Ln S/N ratio) of the good SPEM function group was 4.39+/-0.33(mean+/-s.d.) and that of poor SPEM function group was 3.17+/-0.71. There were no statistically significant differences of age and male/female ratio between the two groups. There were no significant differences of genotype or allele distributions of the Val108/158Met polymorphism on COMT gene between the two schizophrenic groups.
CONCLUSIONS
The results suggest that Val108/158Met polymorphism on COMT gene is not related to SPEM function abnormality in schizophrenia.
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