Korean J Biol Psychiatry.  2006 Nov;13(4):279-288.

Relationship between SNP A and P1763 Polymorphisms on Dystrobrevin Binding Protein 1(DTNBP1) Gene and Smooth Pursuit Eye Movement(SPEM) Abnormality in Korean Schizophrenic Patients

• Lee CH
• Park BL
• Kim LH
• Kim DH
• Cho SH
• Park JS
• Kim IY
• Lee IS
• Seo HG
• Byun KO
• Kim BJ
• Hahn KH
• Kim KH
• Shin TM
• Shin HD
• Woo SI

Abstract

OBJECTIVES
We investigated the association of SNP A and P1763 polymorphisms on dystrobrevin binding protein 1(DTNBP1) gene with smooth pursuit eye movement(SPEM) abnormality in Korean schizophrenic patients.
METHODS
We measured SPEM function in 217 Korean schizophrenics(male 116, female 101) and divided them into two groups, one is a good SPEM function group and the other is a poor SPEM function group. We then analyzed SNP A polymorphism and P1763 polymorphism on DTNBP1 gene from their DNAs extracted from their blood. We compared the differences of genotype and allele distributions of the two polymorphisms on DTNBP1 gene between the two groups.
RESULTS
The Ln S/N ratio(mean+/-SD) of the good SPEM function group was 4.39+/-0.33 and the ratio of poor SPEM function group was 3.17+/-0.71. There were no statistically significant differences of age and male/female ratio between the two groups. There were no significant differences of genotype or allele distributions of the SNP A polymorphism and P1763 polymorphism on DTNBP1 gene between the two schizophrenic groups divided by SPEM function.
CONCLUSION
The results suggest that SNP A polymorphism and P1763 polymorphism on DTNBP1 gene might not be related to SPEM function abnormality in schizophrenia.

Keyword

Schizophrenia; Dystrobrevin binding protein 1(DTNBP1); Smooth pursuit eye movement (SPEM); Genetic polymorphism

MeSH Terms

Alleles
Carrier Proteins*
DNA
Female
Genotype
Humans
Polymorphism, Genetic
Pursuit, Smooth*
Schizophrenia
Carrier Proteins
DNA