Korean J Psychopharmacol.
2006 Nov;17(6):507-516.
Association Analysis between P1635 and P1655 Polymorphisms on Dystrobrevin Binding Protein 1(DTNBP1) Gene and Smooth Pursuit Eye Movement(SPEM) Abnormality in Korean Schizophrenia Patients
- Affiliations
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- 1Keyo Hospital, Euiwang, Korea.
- 2SNP Genetics, Seoul, Korea.
- 3Division of Mental Health, Ministry of Health and Welfare, Gwacheon, Korea.
- 4Department of Neuropsychiatry, Soon Chun Hyang University College of Medicine, Soon Chun Hyang University Hospital, Seoul, Korea. garakman@naver.com
- 5Jinju Mental Hospital, Jinju, Korea.
- 6Department of Psychiatry, Gyeongsang National University College of Medicine, Gyeongsang National University Hospital, Jinju, Korea.
- 7Department of Neuropsychiatry, Soon Chun Hyang University College of Medicine, Buchun Hospital, Bucheon, Korea.
- 8Department of Biomedical Engineering, Yonsei University College of Medicine, Wonju, Korea.
Abstract
OBJECTIVE
We investigated the association of P1635 and P1655 polymorphisms on dystrobrevin binding protein 1 (DTNBP1) gene with smooth pursuit eye movement (SPEM) abnormality in Korean schizophrenia patients.
METHODS
We measured SPEM function in 216 Korean schizophrenia patients (male 116, female 100) and divided them into two groups, one is a good SPEM function group and the other is a poor SPEM function group. We then analyzed P1635 polymorphism and P1655 polymorphism on DTNBP1 gene from their DNAs extracted from their blood. We compared the differences of genotype and allele distributions of the two polymorphisms on DTNBP1 gene between the two groups.
RESULTS
The Ln S/N ratio (mean+/-sd) of the good SPEM function group was 4.39+/-0.33 and the ratio of poor SPEM function group was 3.18+/-0.71. There were no statistically significant differences of age and male/female ratio between the two groups. There were no significant differences of genotype or allele distributions of the P1635 polymorphism and P1655 polymorphism on DTNBP1 gene between the two schizophrenia groups divided by SPEM function.
CONCLUSION
The results suggest that P1635 polymorphism and P1655 polymorphism on DTNBP1 gene might not be related to SPEM function abnormality in schizophrenia.
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