Korean J Anesthesiol.  1997 Dec;33(6):1061-1066. 10.4097/kjae.1997.33.6.1061.

Comparison of Isoflurane and Propofol Anesthesia on Postoperative Nausea, Vomiting and Recovery after Tonsillectomy in Children

• Park SH
• Lee JH
• Lee KN
• Moon JI

• KMID: 2299251
• DOI: http://doi.org/10.4097/kjae.1997.33.6.1061

Abstract

BACKGROUND: The purpose of this study was to compare prospectively two different anesthetic techniques with isoflurane or propofol for postoperative nausea, vomiting and recovery after tonsillectomy in children.
METHODS
Sixty children, ASA physical status I, were assigned randomly to one of two groups. In group I, anesthesia was induced with thiopental 5 mg/kg and maintained with isoflurane 1~1.5 vol%. In group P, anesthesia was induced with fentanyl 1 mcg/kg, propofol 2 mg/kg and maintained with propofol infusion 5~10 mg/kg/hr. Both group received vecuronium 0.1 mg/kg for tracheal intubation and were ventilated with 33% O2 in N2O. The time to extubation, time to eye opening, PACU time, incidence and numbers of postoperative nausea and vomiting, and degree of sedation were recorded as well as perioperative complications.
RESULTS
There were no significant difference in the duration of anesthesia and PACU time between two groups. The time to extubation and eye opening of group P were significantly shorter than group I (p<0.05). The degree of sedation and incidence of postoperative nausea and vomiting of group P were significantly lower than group I (p<0.05). But the frequency of intraoperative bradycardia was significantly higher in group P than group I (p<0.05).
CONCLUSIONS
Propofol-fentanyl anesthesia results in less nausea and vomiting during postoperative period and more rapid recovery compared to isoflurane anesthesia and may be recommended in children undergoing tonsillectomy and adenoidectomy.

Keyword

Anesthetics, intravenous, propofol; Anesthetics, volatile, isoflurane; Surgery, tonsillectomy; Vomiting, nausea, postoperative

MeSH Terms

Adenoidectomy
Anesthesia*
Bradycardia
Child*
Fentanyl
Humans
Incidence
Intubation
Isoflurane*
Nausea
Postoperative Nausea and Vomiting*
Postoperative Period
Propofol*
Prospective Studies
Thiopental
Tonsillectomy*
Vecuronium Bromide
Vomiting*
Fentanyl
Isoflurane
Propofol
Thiopental
Vecuronium Bromide