Korean Diabetes J.  2008 Jun;32(3):224-235. 10.4093/kdj.2008.32.3.224.

Adiponectin Concentrations in Type 2 Diabetic Patients with or without Metabolic Syndrome

• Park JY
• Kim JW
• Kim JM
• Han Y
• Park SK
• Mok JY
• Park MK
• Lee HJ
• Kim DK

• KMID: 2298093
• DOI: http://doi.org/10.4093/kdj.2008.32.3.224

Abstract

BACKGROUND: Adipocytes produce several adipokines that modulate insulin action as well as glucose and lipid metabolism. The aim of this study was to evaluate the relationship between serum adiponectin concentrations and metabolic syndrome (MS) in patients with type 2 diabetes mellitus.
METHODS
This study included 127 type 2 diabetic patients (males 63, females 64). The subjects were divided into two groups as with or without metabolic syndrome (MS(+) or MS(-)). The MS was diagnosed by International Diabetes Federation. Serum adiponectin, leptin, fasting plasma insulin, glucose, glycated hemoglobin, lipid profile, white blood corpuscle (WBC), aspartate aminotransferase (AST), alanine aminotransferase (ALT), uric acid and C-reactive protein (CRP) were examined.
RESULTS
Serum adiponectin concentrations were significantly lower in MS(+) than MS(-) (4.8 +/- 2.4 microgram/mL vs 7.6 +/- 5.8 microgram/mL, 7.6 +/- 3.7 microgram/mL vs 11.5 +/- 7.2 microgram/mL, P < 0.05 in males and females). After adjustment for age and body mass index (BMI), in MS (+), the serum levels of adiponectin correlated positively with high density lipoprotein - cholesterol (HDL-C) and negatively with height, body weight, ALT and CRP. In MS(-), the serum levels of adiponectin correlated positively with HDL-C and negatively with diastolic blood pressure (DBP), triglyceride and CRP. By multiple regression analysis, no parameters were independently correlated with serum adiponectin concentrations in MS(+), while DBP and HDL-C were independently related to serum adiponectin concentrations in MS(-).
CONCLUSION
Serum adiponectin concentrations were lower in type 2 diabetic patients with MS than without MS. There were no significant parameters related to decrease serum adiponectin concentrations in MS. But further study is needed to confirm this result.

Keyword

Adiponectin; Metabolic syndrome; Type 2 diabetes

MeSH Terms

Adipocytes
Adipokines
Adiponectin
Alanine Transaminase
Aspartate Aminotransferases
Blood Pressure
Body Height
Body Mass Index
C-Reactive Protein
Cholesterol
Fasting
Female
Glucose
Hemoglobins
Humans
Insulin
Leptin
Leukocytes
Lipid Metabolism
Lipoproteins
Male
Plasma
Uric Acid
Adipokines
Adiponectin
Alanine Transaminase
Aspartate Aminotransferases
C-Reactive Protein
Cholesterol
Glucose
Hemoglobins
Insulin
Leptin
Lipoproteins
Uric Acid

Figure

• 

  Fig. 1 Serum adiponectin and leptin concectrations in type 2 diabetic patients with metabolic syndrome (MS(+)) and without metabolic syndrome (MS(-)). *P < 0.05 vs MS(-).

• 

  Fig. 2 Serum adiponectin concentrations in subgroups of metabolic syndrome (MS) (panel A). MS(+) HT presents the subgroup of MS with raised blood pressure. MS(+) Dys presents the subgroup of MS with hypertriglyceridaemia and/or low HDL-cholesterol, MS(+) HT+Dys is the subgroup of MS with raised blood pressure and hypertriglyceridaemia and/or low HDL-cholesterol. The serum level of MS(-) was significantly increased than that of each subgroup in MS(+). *P < 0.05 vs MS(+). Serum adiponectin concentrations in MS(+) Dys subgroups (panel B). Dys (TG) presents the subgroup of MS with hypertriglyceridaemia. Dys (HDL) presents the subgroup of MS with low HDL-cholesterol. Dys (TG&HDL) presents the subgroup of MS with hypertriglyceridaemia and low HDL-cholesterol. The serum adiponectin concentrations of each subgroup in MS(+) Dys group were not significantly different between them.

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