Korean J Psychopharmacol.  2013 Oct;24(4):186-189.

Metformin for Treatment of Antipsychotic-Induced Amenorrhea in Female Schizophrenic Patients: Report of Two Cases

Affiliations
  • 1Department of Psychiatry, Yeouido St. Mary's Hospital, The Catholic University of Korea School of Medicine, Seoul, Korea. wmbahk@catholic.ac.kr

Abstract

Amenorrhea is a common adverse event in female patients treated with antipsychotics. Because amenorrhea can produce difficulties for women suffering from schizophrenia, attempts should be made to alleviate antipsychotic-induced amenorrhea. We report two cases of female schizophrenic patients whose antipsychotic-induced amenorrhea were treated with metformin. Two patients who treated with metformin resumed their menstruation within three months. There was no adverse event reported during metformin treatment. This paper presents the rationale for the use of metformin for female patients who suffered from antipsychotic-induced amenorrhea through a literature review.

Keyword

Schizophrenia; Antipsychotic-induced amenorrhea; Metformin

MeSH Terms

Amenorrhea*
Antipsychotic Agents
Female
Female*
Humans
Menstruation
Metformin*
Schizophrenia
Antipsychotic Agents
Metformin
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