- Efficacy and Safety of Pioglitazone versus Glimepiride after Metformin and Alogliptin Combination Therapy: A Randomized, Open-Label, Multicenter, Parallel-Controlled Study
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Kim JM, Kim SS, Kim JH, Kim MK, Kim TN, Lee SH, Lee CW, Park JY, Kim ES, Lee KJ, Choi YS, Kim DK, Kim IJ
- KMID: 2470956
- Diabetes Metab J.
- 2020 Feb;44(1):67-77.
- doi: 10.4093/dmj.2018.0274
BACKGROUND: There is limited information regarding the optimal third-line therapy for managing type 2 diabetes mellitus (T2DM) that is inadequately controlled using dual combination therapy. This study assessed the efficacy... -
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- Metformin Treatment for Patients with Diabetes and Chronic Kidney Disease: A Korean Diabetes Association and Korean Society of Nephrology Consensus Statement
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Hur KY, Kim MK, Ko SH, Han M, Lee DW, Kwon HS, Committee of Clinical Practice Guidelines, Korean Diabetes Association, Committee of the Cooperative Studies, Korean Society of Nephrology
- KMID: 2470951
- Diabetes Metab J.
- 2020 Feb;44(1):3-10.
- doi: 10.4093/dmj.2020.0004
The safety of metformin use for patients with type 2 diabetes mellitus (T2DM) and advanced kidney disease is controversial, and more recent guidelines have suggested that metformin be used cautiously... -
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- Response: Dipeptidyl Peptidase-4 Inhibitors versus Other Antidiabetic Drugs Added to Metformin Monotherapy in Diabetic Retinopathy Progression: A Real World-Based Cohort Study (Diabetes Metab J 2019;43:640–8)
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Chung YR, Ha KH, Lee K, Kim DJ
- KMID: 2466516
- Diabetes Metab J.
- 2019 Dec;43(6):917-918.
- doi: 10.4093/dmj.2019.0216
No abstract available. -
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- Letter: Dipeptidyl Peptidase-4 Inhibitors versus Other Antidiabetic Drugs Added to Metformin Monotherapy in Diabetic Retinopathy Progression: A Real World-Based Cohort Study (Diabetes Metab J 2019;43:640–8)
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Moon JS
- KMID: 2466513
- Diabetes Metab J.
- 2019 Dec;43(6):911-912.
- doi: 10.4093/dmj.2019.0207
No abstract available. -
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- Metformin Ameliorates Lipotoxic β-Cell Dysfunction through a Concentration-Dependent Dual Mechanism of Action
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Kim HI, Lee JS, Kwak BK, Hwang WM, Kim MJ, Kim YB, Chung SS, Park KS
- KMID: 2466506
- Diabetes Metab J.
- 2019 Dec;43(6):854-866.
- doi: 10.4093/dmj.2018.0179
BACKGROUND: Chronic exposure to elevated levels of free fatty acids contributes to pancreatic β-cell dysfunction. Although it is well known that metformin induces cellular energy depletion and a concomitant activation... -
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- Long-term outcomes of progestin plus metformin as a fertility-sparing treatment for atypical endometrial hyperplasia and endometrial cancer patients
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Mitsuhashi A, Habu Y, Kobayashi , Kawarai Y, Ishikawa H, Usui H, Shozu M
- KMID: 2458897
- J Gynecol Oncol.
- 2019 Nov;30(6):e90.
- doi: 10.3802/jgo.2019.30.e90
OBJECTIVE: The present study investigated long-term outcomes of medroxyprogesterone acetate (MPA) plus metformin therapy in terms of control of atypical endometrial hyperplasia (AEH) and endometrial cancer (EC), and post-treatment conception. METHODS:... -
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- Dipeptidyl Peptidase-4 Inhibitors versus Other Antidiabetic Drugs Added to Metformin Monotherapy in Diabetic Retinopathy Progression: A Real World-Based Cohort Study
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Chung YR, Ha KH, Kim HC, Park SJ, Lee K, Kim DJ
- KMID: 2460957
- Diabetes Metab J.
- 2019 Oct;43(5):640-648.
- doi: 10.4093/dmj.2018.0137
BACKGROUND: To investigate the effects of dipeptidyl peptidase-4 inhibitor (DPP4i) as add-on medications to metformin on progression of diabetic retinopathy (DR) in patients with type 2 diabetes mellitus, compared with... -
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- Association of metformin and statin medications with surrogate measures of cardiovascular disease in youth with type 1 diabetes: the SEARCH for diabetes in youth study
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Gourgari E, Stafford J, D'Agostino R, Dolan LM, Lawrence J, Mottl A, Pihoker C, Urbina EM, Wadwa RP, Dabelea D
- KMID: 2460766
- Ann Pediatr Endocrinol Metab.
- 2019 Sep;24(3):187-194.
- doi: 10.6065/apem.2019.24.3.187
PURPOSE: Youth with type 1 diabetes mellitus (T1DM) are at risk of cardiovascular disease (CVD). We evaluated if metformin or statin use was associated with surrogate measures of improved CVD. METHODS:... -
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- Response: Efficacy and Safety of Voglibose Plus Metformin in Patients with Type 2 Diabetes Mellitus: A Randomized Controlled Trial (Diabetes metab J 2019;43;276-86)
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Oh TJ, Choi SH
- KMID: 2455678
- Diabetes Metab J.
- 2019 Aug;43(4):547-548.
- doi: 10.4093/dmj.2019.0148
No abstract available. -
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- Letter: Efficacy and Safety of Voglibose Plus Metformin in Patients with Type 2 Diabetes Mellitus: A Randomized Controlled Trial (Diabetes Metab J 2019;43;276-86)
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Seok H, Sohn TS
- KMID: 2455677
- Diabetes Metab J.
- 2019 Aug;43(4):545-546.
- doi: 10.4093/dmj.2019.0130
No abstract available. -
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- Effectiveness and Safety of Adding Basal Insulin Glargine in Patients with Type 2 Diabetes Mellitus Exhibiting Inadequate Response to Metformin and DPP-4 Inhibitors with or without Sulfonylurea
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Kang YM, Jung CH, Lee SH, Kim SW, Song KH, Kim SG, Kim JH, Cho YM, Park TS, Ku BJ, Koh G, Kim DM, Lee BW, Park JY
- KMID: 2455667
- Diabetes Metab J.
- 2019 Aug;43(4):432-446.
- doi: 10.4093/dmj.2018.0092
BACKGROUND: We aimed to investigate the effectiveness and safety of adding basal insulin to initiating dipeptidyl peptidase-4 (DPP-4) inhibitor and metformin and/or sulfonylurea (SU) in achieving the target glycosylated hemoglobin... -
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- Additional Effect of Dietary Fiber in Patients with Type 2 Diabetes Mellitus Using Metformin and Sulfonylurea: An Open-Label, Pilot Trial
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Lee SE, Choi Y, Jun JE, Lee YB, Jin SM, Hur KY, Ko GP, Lee MK
- KMID: 2455666
- Diabetes Metab J.
- 2019 Aug;43(4):422-431.
- doi: 10.4093/dmj.2018.0090
BACKGROUND: Metformin, sulfonylurea, and dietary fiber are known to affect gut microbiota in patients with type 2 diabetes mellitus (T2DM). This open and single-arm pilot trial investigated the effects of... -
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- Effect of Statins, Metformin, Angiotensin-Converting Enzyme Inhibitors, and Angiotensin II Receptor Blockers on Age-Related Macular Degeneration
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Lee H, Jeon HL, Park SJ, Shin JY
- KMID: 2450408
- Yonsei Med J.
- 2019 Jul;60(7):679-686.
- doi: 10.3349/ymj.2019.60.7.679
PURPOSE: Statins, metformin, angiotensin-converting enzyme (ACE) inhibitors, and angiotensin receptor blockers (ARBs) have been suggested for treating age-related macular degeneration (AMD) due to their pleiotropic effects. Therefore, we investigated whether... -
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- Acarbose Add-on Therapy in Patients with Type 2 Diabetes Mellitus with Metformin and Sitagliptin Failure: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study
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Yang HK, Lee SH, Shin J, Choi YH, Ahn YB, Lee BW, Rhee EJ, Min KW, Yoon KH
- KMID: 2454058
- Diabetes Metab J.
- 2019 Jun;43(3):287-301.
- doi: 10.4093/dmj.2018.0054
BACKGROUND: We evaluated the efficacy and safety of acarbose add-on therapy in Korean patients with type 2 diabetes mellitus (T2DM) who are inadequately controlled with metformin and sitagliptin. METHODS: A total... -
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- Efficacy and Safety of Voglibose Plus Metformin in Patients with Type 2 Diabetes Mellitus: A Randomized Controlled Trial
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Oh TJ, Yu JM, Min KW, Son HS, Lee MK, Yoon KH, Song YD, Park JY, Jeong IK, Cha BS, Kim YS, Baik SH, Kim IJ, Kim DM, Kim SR, Lee KW, Park JH, Lee IK, Park TS, Choi SH, Park SW
- KMID: 2454057
- Diabetes Metab J.
- 2019 Jun;43(3):276-286.
- doi: 10.4093/dmj.2018.0051
BACKGROUND: Combination of metformin to reduce the fasting plasma glucose level and an α-glucosidase inhibitor to decrease the postprandial glucose level is expected to generate a complementary effect. We compared... -
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- Effects of insulin and metformin on fetal kidney development of streptozotocin-induced gestational diabetic albino rats
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Kassab BM, Hussein HH, Mahmoud OM, Abdel-Alrahman G
- KMID: 2451220
- Anat Cell Biol.
- 2019 Jun;52(2):161-175.
- doi: 10.5115/acb.2019.52.2.161
Gestational diabetes mellitus is one of common medical complications of pregnancy. Hyperglycemia in utero impairs renal development and produces renal anomalies. Metformin has antioxidant properties and better glycemic control. Aim:... -
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- Metformin, an Activator of AMPK, Promotes the Growth of Hair Follicles via the AMPK/β-catenin Signaling Pathway
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Moon HR, Park KY, Kang HJ, Lee WJ, Won CH, Chang SE, Lee MW, Choi JH, Park GH
- KMID: 2449198
- Korean J Dermatol.
- 2019 May;57(4):175-181.
BACKGROUND: AMP-activated protein kinase (AMPK) is a serine/threonine protein kinase that plays a pivotal role in the balance of cellular energy metabolism. Recent studies have reported that AMPK has numerous... -
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- The effects of addition of coenzyme Q10 to metformin on sirolimus-induced diabetes mellitus
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Sun IO, Jin L, Jin J, Lim SW, Chung BH, Yang CW
- KMID: 2441016
- Korean J Intern Med.
- 2019 Mar;34(2):365-374.
- doi: 10.3904/kjim.2017.004
BACKGROUND/AIMS: This study was performed to determine whether adding coenzyme Q10 (CoQ(10)) to metformin (MET) has a beneficial effect as a treatment for sirolimus (SRL)-induced diabetes mellitus (DM). METHODS: DM was... -
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- Extracorporeal Membrane Oxygenation and Continuous Renal Replacement Therapy for Treatment of Calcium Channel Blockers, Angiotensin II Receptor Blockers, and Metformin Overdose
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Jeong JH, Sun KH, Park YJ, Kim SP
- KMID: 2437756
- J Korean Soc Clin Toxicol.
- 2018 Dec;16(2):165-171.
- doi: 10.22537/jksct.2018.16.2.165
An overdose of antihypertensive agents, such calcium channel blockers (CCBs) and angiotensin II receptor blocker (ARBs), and the antihyperglycemic agent, metformin, leads to hypotension and lactic acidosis, respectively. A 40-year-old hypertensive... -
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- Absence of antitumor effects of metformin in sorafenib-treated patients with hepatocellular carcinoma recurrence after hepatic resection and liver transplantation
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Chung YK, Hwang S, Song GW, Lee YJ, Kim KH, Ahn CS, Moon DB, Ha TY, Jung DH, Park GC, Ryoo BY, Lee SG
- KMID: 2427359
- Ann Hepatobiliary Pancreat Surg.
- 2018 Nov;22(4):297-304.
- doi: 10.14701/ahbps.2018.22.4.297
BACKGROUNDS/AIMS: Hepatocellular carcinoma (HCC) recurrence following hepatic resection (HR) and liver transplantation (LT) remains a great concern. We assessed the antitumor effects of metformin in patients treated with sorafenib for... -
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