Diabetes Metab J.  2013 Apr;37(2):113-116. 10.4093/dmj.2013.37.2.113.

Metformin and Cancer in Type 2 Diabetes

• Park HK

• KMID: 2280712
• DOI: http://doi.org/10.4093/dmj.2013.37.2.113

Abstract

No abstract available.

MeSH Terms

Metformin
Metformin

Figure

• 

  Fig. 1 Effects of metformin on cancer. Metformin inhibits hepatic gluconeogenesis and stimulates glucose uptake in peripheral tissue, thereby lowering circulating insulin levels, and indirectly reducing phosphatidylinositol-3-kinase (PI3K)/mammalian target of rapamycin (mTOR) signaling. Metformin also activates AMP-activated protein kinase (AMPK) leading to inhibition of mTOR signaling and protein synthesis in cancer cells. Metformin may directly inhibit mTOR signaling [30-32]. IR/IGF-1R, insulin receptor/insulin-like growth factor-1 receptor.

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