Korean J Helicobacter Up Gastrointest Res.  2017 Dec;17(4):179-184. 10.7704/kjhugr.2017.17.4.179.

Chemoprevention of Gastric Cancer: Metformin

• Kim YI
• Cho SJ

• KMID: 2397491
• DOI: http://doi.org/10.7704/kjhugr.2017.17.4.179

Abstract

Metformin is a first-line anti-diabetic drug that has been widely used in patients with type 2 diabetes. Many population-based epidemiologic studies have shown that metformin treatment is associated with decreased risk for various cancers. Recent epidemiologic studies showed that the use of metformin was associated with a reduction in gastric cancer risk, especially in patients with type 2 diabetes who used metformin for long periods of time (>2~3 years). Currently, there are no registered clinical trials investigating the anti-cancer effect of metformin in gastric cancer; hence, further well-designed clinical trials are required. Herein, we review the literature regarding the use of metformin for the prevention of gastric cancer.

Keyword

Chemoprevention; Metformin; Stomach neoplasms

MeSH Terms

Chemoprevention*
Epidemiologic Studies
Humans
Metformin*
Stomach Neoplasms*
Metformin