Korean J Helicobacter Up Gastrointest Res.  2017 Dec;17(4):175-178. 10.7704/kjhugr.2017.17.4.175.

Chemoprevention of Gastric Cancer: Statins

• Choi SH
• Baik GH

• KMID: 2397490
• DOI: http://doi.org/10.7704/kjhugr.2017.17.4.175

Abstract

Gastric cancer is one of the leading causes of cancer-related deaths worldwide. Because the gastric cancer-related mortality rate is expected to increase, chemo-preventive strategies for gastric cancer are required. Statins inhibit 3-hydroxy-3-methylglutaryl coenzyme A reductase, the enzyme involved in the rate-limiting step in cholesterol synthesis. Several studies have shown that statins have potential protective effects against gastric cancer; however, other studies have reported contradictory results. Therefore, further studies are needed to clarify the role of statins in the chemoprevention of gastric cancer.

Keyword

Chemoprevention; Hydroxymethylglutaryl-CoA reductase inhibitors; Stomach neoplasms

MeSH Terms

Chemoprevention*
Cholesterol
Coenzyme A
Hydroxymethylglutaryl-CoA Reductase Inhibitors*
Mortality
Oxidoreductases
Stomach Neoplasms*
Cholesterol
Coenzyme A
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Oxidoreductases