- The Role of Pyruvate Dehydrogenase Kinase in Diabetes and Obesity
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Lee IK
- KMID: 2280687
- Diabetes Metab J.
- 2014 Jun;38(3):181-186.
- doi: 10.4093/dmj.2014.38.3.181
The pyruvate dehydrogenase complex (PDC) is an emerging target for the treatment of metabolic syndrome. To maintain a steady-state concentration of adenosine triphosphate during the feed-fast cycle, cells require efficient... -
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- The Effect of Lovastatin(Mevacor(R)) in Patients with Hypercholesterolemia
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Lee SY, Kyoung CS, Kim DC, Lee KH, Choi SJ, Son I, Park SH
- KMID: 2093279
- Korean Circ J.
- 1991 Apr;21(2):328-336.
- doi: 10.4070/kcj.1991.21.2.328
Lovastatin is a potent inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase, which catalyzes the conversion of hydroxymethylglutaryl-coenzyme A to mevalonate, anearly and rate-limiting step in the synthesis of cholesterol. We studied... -
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- Effect of Pravastatin on Serum Lipids of Patient with Primary Hyperlipidemia
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Yoo WS, Koh WS, Cho BY, Choi SK
- KMID: 2229394
- Korean Circ J.
- 1990 Mar;20(1):128-134.
- doi: 10.4070/kcj.1990.20.1.128
A new hypolipidemic drug, pravastatin, hydroxymethylglutaryl coenzyme A reductase inhibitor was administered to 33 patients with primary hyperlipidemia, 10mg daily for 8 weeks and sequential changes of lipid profile were... -
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- Chemoprevention of Gastric Cancer: Statins
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Choi SH, Baik GH
- KMID: 2397490
- Korean J Helicobacter Up Gastrointest Res.
- 2017 Dec;17(4):175-178.
- doi: 10.7704/kjhugr.2017.17.4.175
Gastric cancer is one of the leading causes of cancer-related deaths worldwide. Because the gastric cancer-related mortality rate is expected to increase, chemo-preventive strategies for gastric cancer are required. Statins... -
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- Mitochondrial Aldehyde Dehydrogenase Precursor Protein and 3-hydroxy-3-methylglutaryl-coenzyme A synthase 2: Two-dimensional Electrophoretic Expressed Protein in the Liver of Acute Alcoholic Abuse
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Yoo SH
- KMID: 2082730
- Korean J Leg Med.
- 2009 May;33(1):65-69.
To study alcohol-related expressed proteins across postmortem livers, human liver tissues from two cadaveric subjects died of acute alcohol abuse and myocardialinfarct were compared. Liver tissues were separated by means... -
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- Effect of Lovastatin(Mevacor(R)) on Serum Lipids of Patients with Primary Hyperlipidemia
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Yoo WS, Lee SB, Ahn JH, Kim K, Lee DC, Rhee KJ, Choi SK
- KMID: 1938159
- Korean Circ J.
- 1989 Sep;19(3):489-496.
- doi: 10.4070/kcj.1989.19.3.489
A new hypolipidemic agent, lovastatin, hydroxy-methyl-gultaryl coenzyme A reductase inhibitor was administred to 25 patients with primary hyperlipidemia 20 to 40 mg daily for 12 weeks and sequential changes of... -
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- Two Siblings with Cerebrotendinous Xanthomatosis
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Park JY, Shin DH, Choi JS, Park MY
- KMID: 2388398
- Korean J Dermatol.
- 2013 Jun;51(6):450-454.
Cerebrotendinous xanthomatosis (CTX) is a rare autosomal recessive lipid storage disease caused by sterol 27-hydroxylase (CYP27) deficiency. We report two CTX siblings that were presented with typical manifestations such as... -
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- Cholesterol Lowering Effects of Low-dose Statins in Korean Patients
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Kwon JE, Kim Y, Hyun S, Won H, Shin SY, Lee KJ, Kim SW, Kim TH, Kim CJ
- KMID: 2198357
- J Lipid Atheroscler.
- 2014 Jun;3(1):21-28.
- doi: 10.12997/jla.2014.3.1.21
OBJECTIVE: The aim of this study is to compare cholesterol lowering effects of low dose 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) in Korean patients. METHODS: A total of 909 consecutive patients... -
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- Gene Expression Analysis for Statin-induced Cytotoxicity from Rat Primary Hepatocytes
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Ko MJ, Ahn JI, Shin HJ, Kim HS, Chung HJ, Jeong HS
- KMID: 2166476
- Genomics Inform.
- 2010 Mar;8(1):41-49.
Statins are competitive inhibitors of hydroxy-3-methyl glutaryl coenzyme A (HMG-CoA) reductase and used most frequently to reduce plasma cholesterol levels and to decrease cardiovascular events. However, statins also have been... -
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- Nonalcoholic fatty liver disease: molecular mechanisms for the hepatic steatosis
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Koo SH
- KMID: 1705200
- Clin Mol Hepatol.
- 2013 Sep;19(3):210-215.
- doi: 10.3350/cmh.2013.19.3.210
Liver plays a central role in the biogenesis of major metabolites including glucose, fatty acids, and cholesterol. Increased incidence of obesity in the modern society promotes insulin resistance in the... -
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- Hypocholesterolemic metabolism of dietary red pericarp glutinous rice rich in phenolic compounds in mice fed a high cholesterol diet
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Park Y, Park EM, Kim EH, Chung IM
- KMID: 2313789
- Nutr Res Pract.
- 2014 Dec;8(6):632-637.
- doi: 10.4162/nrp.2014.8.6.632
BACKGROUND/OBJECTIVES: The purpose of the current study was to investigate the effect of red pericarp glutinous rice rich in polyphenols (Jakwangchalbyeo, red rice) on serum and hepatic levels of cholesterol... -
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- Effect of Hydroxymethyl Glutaryl Coenzyme A Reductase Inhibitor on High Sensitivity C-Reactive Protein Levels in Hypercholesterolemic Patients without Atherosclerotic Diseases
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Jung KS, Lee KE, Lee SH, Kim SJ, Lee KJ, Kim SW, Kim TH, Ko HS, Kim CJ, Ryu WS, Park AJ
- KMID: 2294364
- Korean Circ J.
- 2004 Apr;34(4):381-387.
- doi: 10.4070/kcj.2004.34.4.381
BACKGROUND AND OBJECTIVES: High C-reactive protein (CRP) levels are associated with an increased risk of cardiovascular diseases. The hydroxymethyl glutaryl Coenzyme A reductase inhibitors (statin) lowers the CRP level in... -
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- Nicorandil alleviated cardiac hypoxia/reoxygenation-induced cytotoxicity via upregulating ketone body metabolism and ACAT1 activity
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Bai YP, Han LS
- KMID: 2443614
- Korean J Physiol Pharmacol.
- 2019 Jan;23(1):37-45.
- doi: 10.4196/kjpp.2019.23.1.37
To study the effect of nicorandil pretreatment on ketone body metabolism and Acetyl-CoA acetyltransferase (ACAT1) activity in hypoxia/reoxygenation (H/R)-induced cardiomyocytes. In our study, we applied H9c2 cardiomyocytes cell line to... -
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- Physiological Functionality and Enzyme Activity of Biomass from Pichia anomala Grown on Ginseng-Steaming Effluent
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Kim NM, So SH, Lee SG, Song JE, Seo DS, Lee JS
- KMID: 1487334
- Mycobiology.
- 2008 Sep;36(3):148-151.
- doi: 10.4489/MYCO.2008.36.3.148
A novel biomass was prepared from Pichia anomala KCCM 11473, which grew well in ginseng-steaming effluent (GSE), and its physiological functionalities and enzyme activities were determined. When the strain was... -
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- Effect of Atorvastatin, a HMG-CoA Reductase Inhibitor, in Experimental Colitis in Mice
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Park HJ, Kim TW, Seo JN, Oh KI, Choi EY, Shin HS, Park YE
- KMID: 2277695
- Korean J Pathol.
- 2004 Dec;38(6):401-407.
BACKGROUND: The statins, 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, are approved for cholesterol reduction, and may also be beneficial in the treatment of inflammatory disease. In this study, atorvastatin was tested... -
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- Comparison of Adverse Events between High-intensity and Moderate- to Low-intensity Statin Group
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Lee S, Ock M, Kim H
- KMID: 2437933
- Korean J Clin Pharm.
- 2018 Dec;28(4):293-299.
- doi: 10.24304/kjcp.2018.28.4.293
BACKGROUND: 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) effectively reduce serum levels of low-density lipoprotein (LDL) and total cholesterol. High-intensity statins are recommended for all patients aged ≤75 with clinical atherosclerotic... -
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- The Risk of Rosacea According to Chronic Diseases and Medications: A 5-Year Retrospective, Multi-Institutional Case-Control Study
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Son JH, Chung BY, Jung MJ, Choi YW, Kim HO, Park CW
- KMID: 2428923
- Ann Dermatol.
- 2018 Dec;30(6):676-687.
- doi: 10.5021/ad.2018.30.6.676
BACKGROUND: Rosacea is associated with chronic systemic disease. However, research is lacking in Asian countries. OBJECTIVE: To evaluate the association between rosacea and cardiovascular diseases (CVDs) related systemic comorbidities, and the... -
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- The Effects of Simvastatin on Bone Healing in Mandible Fractured Rats
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Jeong JO, Kwon YS, Kim SK, Lee KC
- KMID: 2322197
- J Korean Soc Plast Reconstr Surg.
- 2009 Sep;36(5):525-530.
PURPOSE: The hydroxymethylglutaryl coenzyme A reductase inhibitors (statins) are widely used in the treatment of dyslipidemia for lowering of cholesterol level. And the studies in simvastatins have shown to enhance... -
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- Intractable metabolic acidosis in a child with propionic acidemia undergoing liver transplantation: a case report
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Ryu J, Shin YH, Ko JS, Gwak MS, Kim GS
- KMID: 2239727
- Korean J Anesthesiol.
- 2013 Sep;65(3):257-261.
- doi: 10.4097/kjae.2013.65.3.257
Propionic acidemia (PA) is a rare autosomal recessive disorder of metabolism caused by deficient activity of the mitochondrial enzyme propionyl-CoA carboxylase. The clinical manifestations are metabolic acidosis, poor feeding, lethargy,... -
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- Comparative pharmacokinetic and tolerability evaluation of two simvastatin 20 mg formulations in healthy Korean male volunteers
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Moon SJ, Lee S, Jang K, Yu KS, Yim SV, Kim BH
- KMID: 2411413
- Transl Clin Pharmacol.
- 2017 Mar;25(1):10-14.
- doi: 10.12793/tcp.2017.25.1.10
Simvastatin is used to reduce plasma cholesterol by inhibiting 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase and is primarily used to treat hypercholesterolemia. This study was conducted to assess the bioequivalence between... -
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