Ann Dermatol.  2018 Dec;30(6):676-687. 10.5021/ad.2018.30.6.676.

The Risk of Rosacea According to Chronic Diseases and Medications: A 5-Year Retrospective, Multi-Institutional Case-Control Study

  • 1Department of Dermatology, Hallym University Kangnam Sacred Heart Hospital, College of Medicine, Hallym University, Seoul, Korea.


Rosacea is associated with chronic systemic disease. However, research is lacking in Asian countries.
To evaluate the association between rosacea and cardiovascular diseases (CVDs) related systemic comorbidities, and the use of antihypertensive and antihyperlipidemic drugs in Korea.
A five-year retrospective study, using hospital database, was conducted in five medical centers for five years. Totally 1,399,528 patients were evaluated.
The overall frequency for diagnosed rosacea was 0.18% over five years (2,536 rosacea patients). Patients with diabetes and patients with dyslipidemia were more likely to have rosacea (odd ratio [OR] 2.724, 95% confidence interval [CI] 1.295~5.730, p=0.016; OR 1.788, 95% CI 1.445~2.212, p < 0.001). Patients with CVD were less likely to have rosacea (OR 0.431, 95% CI 0.244~0.760, p=0.003). Patients with α-blocker prescriptions and patients with β-blocker prescriptions showed a tendency diagnosed with rosacea frequently (OR 1.963, 95% CI 1.200~3.212, p=0.006; OR 3.939, 95% CI 3.512~4.419, p < 0.001). Patients with [beta]-hydroxy-[beta]-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, and those with fibrate, were prone to have rosacea (OR 1.599, 95% CI 1.390~1.839, p < 0.001; OR 1.660, 95% CI 1.056~2.609, p=0.026). As adjusted results, among the patients who took HMG-CoA reductase inhibitor without dyslipidemia, rosacea was less likely to be diagnosed (OR 0.780, 95% CI 0.620~0.982, p=0.034).
Rosacea is associated with chronic diseases and drugs.


Antihypertensive agents; Cardiovascular diseases; Chronic disease; Hyperlipidemias; Rosacea

MeSH Terms

Antihypertensive Agents
Asian Continental Ancestry Group
Cardiovascular Diseases
Case-Control Studies*
Chronic Disease*
Coenzyme A
Retrospective Studies*
Antihypertensive Agents
Coenzyme A


  • Fig. 1 Changes in the frequency of diagnosed rosacea by sex in five medical centers for five years.

  • Fig. 2 Risk of diagnosed rosacea according to chronic systemic diseases. IHD: ischemic heart disease, CVD: cardiovascular disease. *p<0.05.

  • Fig. 3 Risk of diagnosed rosacea in relation to medications such as antihypertensive and antihyperlipidemic drugs. CCB: calcium channel blocker, ACEi: angiotensin-converting-enzyme inhibitor, ARB: angiotensin II receptor blocker, HMG-CoA: [beta]-hydroxy-[beta]-methylglutaryl coenzyme A, ASA: aspirin. *p<0.05.

  • Fig. 4 (A) Risk of diagnosed rosacea according to specific diuretics, (B) risk of diagnosed rosacea according to specific α-blockers and β-blocker, classified drugs by subtypes. *p<0.05.

  • Fig. 5 Odds ratio for the risk of diagnosed rosacea in (A) total population, (B) males, and (C) females, after subdivided analysis. HMG-CoA: [beta]-hydroxy-[beta]-methylglutaryl coenzyme A, CVA: cerebrovascular attack, ASA: aspirin. *p<0.05.


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