Korean J Psychopharmacol.  1997 Apr;8(1):101-106.

Relationship between Therapeutic Response and Plasma HVA/5-HIAA Ratio in Newly Admitted Schizophrenia

• Koo HD
• Suh HS
• Kim KH
• Kim CE

Abstract

Twenty newly admitted acute schizophrenic patients were treated with haloperidol for 6 weeks. HVA and 5-HIAA were sampled at baseline, 3days after initial neuroleptic dose, and after 1, 2, 3, 4, 6 weeks of treatment. Nine patients were classified as responders in this prospective haloperidol treatment trial. They had a score of change in the BPRS total scores of 25% or greater. Eleven patients were classified as nonresponders, based on a score of changes in the BPRS total scores of less than 25%. 1) There was no significant difference in plasma HVA/5-HIAA ratio between responder and non-responder before and after haloperidol treatment. 2) There was no significant correlations between plasma HVA/5-HIAA ratio and BPRS total scores. This study could not support the hypothesis that neuroleptic treatment would be effective by changing dopamine and serotonin function and/or by altering their interaction.

Keyword

Schizophernia; Responder; Non-responder; Plasma HVA/5-HIAA ratio

MeSH Terms

Dopamine
Haloperidol
Humans
Hydroxyindoleacetic Acid
Plasma*
Prospective Studies
Schizophrenia*
Serotonin
Dopamine
Haloperidol
Hydroxyindoleacetic Acid
Serotonin