Korean J Psychopharmacol.  1997 Oct;8(2):249-256.

Relationship between Urine HVA and 5-HIAA Concentrations and Symptoms in Chronic Schizophrenia

• Shin SJ
• Woo HW

Abstract

OBJECTS: This study was purposed to investigate the relationship between urine HVA and 5-HIAA concentrations and clinical symptoms in chronic schizophrenia.
METHODS
272 patients with chronic schizophrenia, diagnosed by DSM-IV criteria, were performed to measure urine HVA and 5-HIAA concentrations and to evaluate the clinical symptoms by using BPRS, PANSS, YBOCS and HAM-D.
RESULTS
Urine HVA and 5-HIAA concentrations showed significant correlation with BPRS, positive scale, negative scale and general psychopathology in PANSS and urine HVA/5-HIAA ratios found no significant correlation. Urine HVA concentrations showed significant correlattion with urine 5-HIAA concentrations and urine HVA/5-HIAA ratios had a negative correlation with urine 5-HIAA concentration. As a result of stepwise multiple regression, urine HVA concentrations were significantly correlated with BPRS and positive scale in PANSS and Urine 5-HIAA concentrations were significantly correlated with BPRS. Urine HVA/5-HIAA ratios had significant correlation with HAM-D and BPRS.
CONCLUSION
These findings support the hypothesis that the role of central dopamine and serotonin system and the functional interaction of both neurotransmitters are important to clinical symptom formation of chronic schizophrenia.

Keyword

Schizophrenia; Urine HVA concentration; Urine 5-HIAA concentration

MeSH Terms

Diagnostic and Statistical Manual of Mental Disorders
Dopamine
Humans
Hydroxyindoleacetic Acid*
Neurotransmitter Agents
Psychopathology
Schizophrenia*
Serotonin
Dopamine
Hydroxyindoleacetic Acid
Neurotransmitter Agents
Serotonin