Korean J Psychopharmacol.
2004 Dec;15(4):425-432.
Effectiveness and Tolerability of Topiramate Versus Divalproex in Bipolar Mania
- Affiliations
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- 1Department of Psychiatry, St. Mary's Hospital, The Catholic University of Korea College of Medicine, Seoul, Korea.
- 2Department of Psychiatry, Kangbuk Samsung Hospital, Sungkyunkwan University, School of Medicine, Seoul, Korea.
- 3Department of Neuropsychiatry, Seoul Paik Hospital, Inje University, Seoul, Korea.
- 4Department of Psychiatry, National Naju Hospital, Naju, Korea.
- 5Department of Neuropsychiatry, Kangnam Sacred Heart Hospital, College of Medicine, Hallym University, Seoul, Korea.
- 6Department of Neuropsychiatry, National Health Insurance Incorporation Ilsan Hospital, Koyang, Korea.
- 7Department of Psychiatry, Chonbuk National University Medical School, Jeonju, Korea.
- 8Department of Psychiatry, Kangnam St. Mary's Hospital, The Catholic University of Korea College of Medicine, Seoul, Korea. pae@catholic.ac.kr
Abstract
- Mood stabilizers and atypical antipsychotics are commonly combined for the treatment of bipolar mania. The aim of this study was to compare the effectiveness and tolerability of topiramate and divalproex in combination with risperidone for treating acute mania patients in a naturalistic treatment setting. Seventy-four patients who met the DSM-IV criteria for bipolar mania were enrolled in this study. In order to assess the efficacy and the extrapyramidal symptoms, the Young Mania Rating Scale (YMRS), Clinical Global Impression (CGI) and Simpson-Angus Rating Scale were measured at the baseline and at weeks 1, 3 and 6. From the baseline to the endpoint, the YMRS and CGI scores were reduced by 67.9% and 56.6% in the topiramate group. The YMRS and CGI scores were also reduced by 63.7% and 58.2% in the divalproex group. The weight and BMI increased significantly by 3.6% and 3.3% from the baseline to the endpoint in the divalproex group, while they decreased by 0.4% and 0.5%, respectively, with no significant difference in the topiramate group. There were no serious adverse events in either group. Topiramate is effective and tolerable for treating acute mania, and may also be a promising alternative to a weightgain liable mood stabilizer such as divalproex.
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