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Real-world Evaluation of Tolerability, Safety and Efficacy of Rivastigmine Oral Solution in Patients with Mild to Moderate Alzheimer’s Disease Dementia

Hsieh SW, Chen JC, Chen NC, Jhang KM, Wang W, Yang YH

Objective: The purpose of this study is to investigate the safety, tolerability and efficacy of titrating dose of rivastigmine oral solution in patients with mild to moderate Alzheimer’s disease (AD)...
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Cariprazine Add-on in Inadequate Clozapine Response: A Report on Two Cases

Berardis DD, Rapini G, Olivieri L, Giardini A, Lauretis ID, Serroni N, Orsolini L, Fornaro M, Iasevoli F, Trotta S, Cottura P, Vellante F, Alessandrini M, Giannantonio MD

Cariprazine is a novel antipsychotic drug that exerts partial agonism of dopamine D2 /D3 receptors with preferential binding to the D 3 receptor, antagonism of 5HT2B receptors, and partial agonism...
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Effectiveness and Tolerability of Switching to Aripiprazole Once Monthly from Antipsychotic Polypharmacy and/or Other Long Acting Injectable Antipsychotics for Patients with Schizophrenia in Routine Practice: A Retrospective, Observation Study

Pae CU, Han C, Bahk WM, Lee SJ, Patkar AA, Masand PS

Objective: This study was done for collection of real world data of Aripiprazole Once Monthly (AOM) in patients with schizophrenia. Methods: The observation was up to 12 months from the first...
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The Potential Utility of Aripiprazole Augmentation for Major Depressive Disorder with Mixed Features Specifier: A Retrospective Study

Han C, Wang SM, Bahk WM, Lee SJ, Patkar AA, Masand PS, Pae CU

OBJECTIVE: The present study aimed to observe potential benefit of aripiprazole augmentation in the treatment of major depressive disorder with mixed specifier (MDDM) in naturalistic treatment setting. METHODS: Data were collected...
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Temsirolimus in Asian Metastatic/Recurrent Non-clear Cell Renal Carcinoma

Lee JB, Park HS, Park S, Lee HJ, Kwon KA, Choi YJ, Kim YJ, Nam CM, Cho NH, Kang B, Chung HC, Rha SY

PURPOSE: Temsirolimus is effective in the treatment for metastatic non-clear cell renal cell carcinoma (nccRCC) with poor prognosis. We aim to investigate the efficacy and tolerability of temsirolimus in treatment...
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Serum N-Desmethylcitalopram Concentrations are Associated with the Clinical Response to Citalopram of Patients with Major Depression

Ozbey G, Yucel B, Bodur NE, Taycan SE, Arslan T, Cerit N, Yuksel N, Guzey IC, Uluoglu C

OBJECTIVE: Citalopram (CITA) is a widely used and well-tolerated selective serotonin reuptake inhibitor. The aim of the study was to evaluate the possible influences of serum concentrations of CITA and...
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Rufinamide in Patients with Childhood Onset Intractable Epilepsy

Ahn H, Yum MS, Yeh HR, Kim MJ, Ko TS

PURPOSE: This study is aimed to evaluate the effectiveness and tolerability of rufinamide as add-on therapy in patients with intractable epilepsies. METHODS: We retrospectively reviewed the medical records of 70 patients...
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Efficacy and Tolerability of Solifenacin 5 mg Fixed Dose in Korean Children with Newly Diagnosed Idiopathic Overactive Bladder: a Multicenter Prospective Study

Lee SD, Chung JM, Kang DI, Ryu DS, Cho WY, Park S

We investigated the efficacy and tolerability of solifenacin 5 mg fixed dose in children with newly diagnosed idiopathic overactive bladder (OAB). A total of 34 children (male/female patients = 16/18)...
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Comparison of R(+)-α-lipoic acid exposure after R(+)-α-lipoic acid 200 mg and 300 mg and thioctic acid 600 mg in healthy Korean male subjects

Yoon J, Moon SJ, Lee KO, Yoon SH, Jang IJ, Yu KS, Lee S

Alpha-lipoic acid, a physiological form of thioctic acid, is a strong antioxidant that relieves diabetic neuropathic symptoms. R(+)-α-lipoic acid shows superior antioxidative effects to its racemate. We compared the pharmacokinetics...
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Efficacy and Tolerability of Paliperidone Extended-release in the Treatment of First-episode Psychosis: An Eight-week, Open-label, Multicenter Trial

Kang NI, Koo BH, Kim SW, Kim JH, Nam B, Lee BJ, Lee SH, Lee SJ, Lee SH, Jung MH, Hahn SW, Chung YC

OBJECTIVE: We investigated the efficacy and tolerability of paliperidone extended-release (ER) tablets in patients with first-episode psychosis (n=75). METHODS: This was an 8-week, open-label, multicenter trial. The primary outcome variable was...
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Efficacy and Tolerability of Generic Mirtazapine (Mirtax) for Major Depressive Disorder: Multicenter, Open-label, Uncontrolled, Prospective Study

Song HR, Bahk WM, Woo YS, Jeong JH, Kwon YJ, Seo JS, Kim W, Kim MD, Shin YC, Lee SY, Min KJ

OBJECTIVE: Mirtax is a generic mirtazapine widely used since 2003. We conducted an open-label, uncontrolled 6-week study to evaluate the efficacy and safety of Mirtax for major depressive disorder (MDD). METHODS:...
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Factors Influencing Skin Tolerability to the Rivastigmine Patch in Patients with Alzheimer's Disease

Na HR, Park MH, Kim S, Yang DW, Choi SH, Yang HD, Yang Y, Han HJ, Lee JS, Yoon YC, Koh SH, Kim JE, Ku BD, Kim HJ, Park KW, Kim EJ, Yoon B, Park KJ

BACKGROUND AND PURPOSE: The one-day rivastigmine patch is reportedly well tolerated and has minimal side effects. However, Asian patients show more side effects than those in Western countries. We evaluated...
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Efficacy and Tolerability of Anticholinergics in Korean Children with Overactive Bladder: A Multicenter Retrospective Study

Park SJ, Pai KS, Kim JM, Park K, Kim KS, Song SH, Park S, Kim SO, Ryu DS, Baek M, Lee SD, Lee JW, Im YJ, Han SW, Chung JM, Cho MH, Ha TS, Cho WY, Suh HJ, The Korean Children's Continence and Enuresis Society

We investigated the efficacy and tolerability of various anticholinergics in Korean children with non-neurogenic overactive bladder (OAB). A total of 326 children (males:females= 157:169) aged under 18 yr (mean age...
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Efficacy and Tolerability of Valproic Acid Once Daily Dosing for Juvenile Myoclonic Epilepsy

Choi SA, Kim SY, Yoo IH, Ryu HW, Kim H, Lim BC, Hwang H, Chae JH, Choi J, Kim KJ, Hwang YS

  • KMID: 2329258
  • J Korean Child Neurol Soc.
  • 2014 Jun;22(2):47-51.
PURPOSE: The purpose of this study was to evaluate the efficacy and tolerability of extended-release valproic acid once daily dosing in juvenile myoclonic epilepsy (JME). METHODS: Medical records of patients who...
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Long-Term Tolerability of Escitalopram in Korean Adolescents

Goo AJ, Won EK, Lee C, Lee JI, Jung HY, Kim Y

  • KMID: 2291617
  • J Korean Acad Child Adolesc Psychiatry.
  • 2013 Dec;24(4):207-212.
OBJECTIVES: We investigated the long-term tolerability of escitalopram in Korean adolescents. METHODS: The subjects were 37 adolescents, who had been diagnosed with depressive disorder in accordance to DSM-IV. Clinical effectiveness was...
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Pharmacokinetic Characteristics of Cefcapene Pivoxil Hydrochloride after Single Oral Administration in Healthy Korean Subjects

Rhee SJ, Shin KH, Cha YJ, Kim JR, Oh DS, Cho JY, Yu KS, Jang IJ, Chung JY, Lim KS

BACKGROUND: Cefcapene pivoxil hydrochloride (CFPN-PI) is an oral ester cephalosporin antibiotic with a broad spectrum. In this study, we investigated the pharmacokinetics (PK) and tolerability of CFPN-PI following single oral...
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Review of Antidepressants Treatment in Late-Life Depression

Yoon JH, Park SJ

  • KMID: 2334525
  • J Korean Geriatr Psychiatry.
  • 2013 Jun;17(1):8-13.
Late-life depression (LLD) refers to depressive syndromes defined in the Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DSM-IV) and in the International Classification of Diseases-10 (ICD-10) that arise...
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Effectiveness and Tolerability of Fosphenytoin for Pediatric Status Epilepticus

Hong WG, Yoo IH, Kim JS, Ryu HW, Byun SH, Kim H, Lim BC, Chae JH, Choi J, Kim KJ, Hwang YS, Hwang H

  • KMID: 2329619
  • J Korean Child Neurol Soc.
  • 2013 Mar;21(1):1-6.
PURPOSE: The study was aimed to investigate the effectiveness and tolerability of intravenous fosphenytoin (fPHT) in the treatment of pediatric status epilepticus (SE). METHODS: Medical-records of patients who received intravenous (IV)...
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Tolerability, Safety and Effectiveness of Paliperidone ER in Patients with Schizophrenia : A 24-Week Interim Analysis of the 48-Week Open-Label, Prospective, Switch Study

Choi YR, Jung DC, Kim EY, Kim SH, Lee HJ, Lee NY, Chang SM, Shim JC, Joo EJ, Kim JJ, Lee SH, Chung YC, Kim YS, Ahn YM

  • KMID: 2299870
  • Korean J Biol Psychiatry.
  • 2013 Feb;20(1):12-20.
OBJECTIVES: We investigated the tolerability, safety, and treatment response to flexible-dose paliperidone ER in patients with non-acute schizophrenia in whom previous antipsychotic drugs were ineffective. METHODS: This 24-week interim analysis of...
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Retrospective Analyses of Long-Term Use of SSRI in Children and Adolescents with Autism Spectrum Disorder

Goo AJ, Park JP, Lee JI, Jhin HK, Kim Y

  • KMID: 2250353
  • Korean J Biol Psychiatry.
  • 2012 Nov;19(4):205-210.
OBJECTIVES: The purpose of this study was to investigate clinical profile, efficacy, and safety of long-term treatment with selective serotonin reuptake inhibitors (SSRIs) in Korean autism spectrum disorders (ASDs) patients. METHODS:...
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