Korean J Pediatr.  2014 Dec;57(12):533-537. 10.3345/kjp.2014.57.12.533.

The relationship between serum adiponectin and inflammatory cytokines in obese Korean juveniles

• Byun SH
• Kwon EB
• Kim SY

• KMID: 2284643
• DOI: http://doi.org/10.3345/kjp.2014.57.12.533

Abstract

PURPOSE
Obesity is related to systemic inflammatory processes causing cardiovascular complications. Intercellular adhesion molecule-1 (ICAM-1), CD40 ligand (CD40L), P-selectin are newly described mediators of inflammation and have a significant effect in atherosclerosis. Adiponectin has shown anti-inflammatory effects in adults. The aim of this study was to evaluate the relationship between adiponectin and inflammatory mediators in children and adolescents.
METHODS
Fifty children or adolescents, twenty two with a body mass index (BMI) over 95th percentile, and twenty eight with a BMI below 75th percentile were included in the study. Serum soluble ICAM-1 (sICAM-1), P-selectin, CD40L, lipid profiles, aspartate aminotransferase, alanine aminotransferase, glucose and insulin were measured to evaluate associations with adiponectin. Comparison of these variables was performed between the obese and the nonobese group.
RESULTS
We found a adiponectin to be significant lower and sICAM-1 significant higher in the obese group compared to the nonobese group, but there were no significant differences in P-selectin and soluble CD40L. Adiponectin was negatively associated with ICAM-1 and P-selectin in the obese group.
CONCLUSION
Negative associations of adiponectin with ICAM-1 and P-selectin in obese children and adolescents suggest that serum adiponectin level may represent the inflammatory status.

Keyword

Adiponectin; Intercellular adhesion molecule-1; CD40 ligand; P-selectin

MeSH Terms

Adiponectin*
Adolescent
Adult
Alanine Transaminase
Aspartate Aminotransferases
Atherosclerosis
Body Mass Index
CD40 Ligand
Child
Cytokines*
Glucose
Humans
Inflammation Mediators
Insulin
Intercellular Adhesion Molecule-1
Obesity
P-Selectin
Adiponectin
Alanine Transaminase
Aspartate Aminotransferases
CD40 Ligand
Cytokines
Glucose
Inflammation Mediators
Insulin
Intercellular Adhesion Molecule-1
P-Selectin